5-Bromo-2-methoxy-4-methylpyridine
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- CAS-Nr.
- 164513-39-7
- Englisch Name:
- 5-Bromo-2-methoxy-4-methylpyridine
- Synonyma:
- 5-Bromo-2-methoxy-4-methyL;2-METHOXY-5-BROMO-4-PICOLINE;5-BROMO-2-METHOXY-4-PICOLINE;5-BROMO-2-METHOXY-4-METHYLPYRIDIN;2-METHOXY-5-BROMO-4-METHYLPYRIDINE;5-BROMO-2-METHOXY-4-METHYLPYRIDINE;Pyridine, 5-bromo-2-methoxy-4-methyl-;5-Bromo-2-methoxy-4-methylpyridine >5-BROMO-2-METHOXY-4-METHYLPYRIDINE, 96+%;5-BROMO-2-METHOXY-4-METHYLPYRIDINE ISO 9001：2015 REACH
- CBNumber:
- CB2411116
- Summenformel:
- C7H8BrNO
- Molgewicht:
- 202.05
- MOL-Datei:
- 164513-39-7.mol
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5-Bromo-2-methoxy-4-methylpyridine Eigenschaften
- Schmelzpunkt:
- 33-37 °C(lit.)
- Siedepunkt:
- 229.6±35.0 °C(Predicted)
- Dichte
- 1.45g/ml
- Flammpunkt:
- 225 °F
- storage temp.
- 0-10°C
- pka
- 1.70±0.18(Predicted)
- Aggregatzustand
- powder to crystal
- Farbe
- White to Almost white
- InChIKey
- HTBPXLJKMNBQMS-UHFFFAOYSA-N
- CAS Datenbank
- 164513-39-7(CAS DataBase Reference)
5-Bromo-2-methoxy-4-methylpyridine Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Synthese
Sodium acetate (3.54g. 43.23mmol) was added to a solution of 2-methoxy-4-methylpyridine (5.0g.3gmmol) in EtOAc (25mL). Br2 (1 .52mL, 58mmol) was added drop-wise to over 20 mm at 0°C. The RM was stirred at 50°C for 18 h. The total reaction mass was cooled, and after diluting it with water, the pH was adjusted to 8 with aq. NaOH. The organic layer was separated, and aq. Layer extracted with EtOAc (250mL x 3). The combined extract was washed with water (300 mL), brine (200 mL), dried (Na2SO4) and concentrated under reduced pressure to get a crude compound. The crude compound was purified by CC(silica gel 100-200mesh, 0-5 per cent EtOAc in PE) to obtain 5-bromo-2-methoxy-4-methylpyridine (2.82g. 40 per cent) as liquid.
5-Bromo-2-methoxy-4-methylpyridine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Bromo-2-methoxy-4-methylpyridine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 206)Lieferanten
- 5-BROMO-2-METHOXY-4-METHYLPYRIDINE
- 5-BROMO-2-METHOXY-4-PICOLINE
- 5-BROMO-2-METHOXY-4-METHYLPYRIDINE, 96+%
- 2-METHOXY-5-BROMO-4-PICOLINE
- 2-METHOXY-5-BROMO-4-METHYLPYRIDINE
- 5-BroMo-2-Methoxy-4-Methylpyridine
- 5-Bromo-2-methoxy-4-methylpyridine
5-Bromo-2-methoxy-4-picoline
- 5-BROMO-2-METHOXY-4-METHYLPYRIDIN
- 5-Bromo-2-methoxy-4-methylpyridine >
- 5-Bromo-2-methoxy-4-methyL
- Pyridine, 5-bromo-2-methoxy-4-methyl-
- 5-BROMO-2-METHOXY-4-METHYLPYRIDINE ISO 9001：2015 REACH
- 164513-39-7
- Building Blocks
- Pyridines
- Halogenated Heterocycles
- Heterocyclic Building Blocks
- Isoquinolines ,Quinolines ,Quinazolines ,Quinaldines
- Pyridine Series
- Heterocyclic Building Blocks
- Pyridines
- Pyridine
- Heterocyclic Compounds
- Heterocycles
- Boronic Acid
- C7 and C8Heterocyclic Building Blocks
- Halogenated Heterocycles
