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(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE Struktur
451462-58-1
CAS-Nr.
451462-58-1
Englisch Name:
(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE
Synonyma:
H1152;H1152P;H-1152;H 1152;H1152;(S)-H-1152 dihydrochloride;(S)-H-1152 (hydrochloride);(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE;4-methyl-5-[(2-methyl-1,4-diazepan-1-yl)sulfonyl]isoquinoline,dihydrochloride;Isoquinoline, 5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methyl-;(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepinedihydrochloride
CBNumber:
CB2377081
Summenformel:
C16H21N3O2S
Molgewicht:
319.42
MOL-Datei:
451462-58-1.mol

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE Eigenschaften

Siedepunkt:
519.6±60.0 °C(Predicted)
Dichte
1.218±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at +4°C
L?slichkeit
25℃: DMSO
Aggregatzustand
Powder
pka
9.76±0.40(Predicted)
Farbe
Off-white to light yellow
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H318 Verursacht schwere Augensch?den. Schwere Augensch?digung Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P280, P305+P351+P338, P310
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Rho-associated kinase (ROCK), activated by GTP-linked Rho, phosphorylates targets that are involved in cytoskeletal remodeling, smooth muscle contraction, and neuronal development. H-1152 is a potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM). It is a more potent inhibitor of ROCK than either Y-27632 (Ki = 140 nM) or HA-1077 (Ki = 330 nM). H-1152 poorly inhibits PKA, PKC, and myosin light chain kinase (Ki = 0.63, 9.27, and 10.1 μM, respectively). It has been used to examine the role of ROCK in such diverse processes as stress fiber assembly, vasoconstriction, as well as spontaneously tonic smooth muscle and neurite extension.

Biologische Aktivit?t

Rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC 50 values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μ M for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea pig aorta (IC 50 = 190 nM) and displays proerectile effects in rats.

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 50)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2922 55
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
VDM Biochemicals 0330-2528181
sales@vdmbio.com United States 510 64
AdooQ BioScience, LLC +1 (866) 930-6790
info@adooq.com United States 2782 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057
 3003855609@qq.com China 7787 56
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189
 mychess007@163.com China 1994 55
AdooQ Bioscience CHINA 025-58849295 18951903616;
 info@adooq.cn China 2990 60
  • (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepinedihydrochloride
  • H1152
  • H1152P
  • (S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE
  • (S)-H-1152 (hydrochloride)
  • (S)-H-1152 dihydrochloride
  • H-1152;H 1152;H1152
  • 4-methyl-5-[(2-methyl-1,4-diazepan-1-yl)sulfonyl]isoquinoline,dihydrochloride
  • Isoquinoline, 5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methyl-
  • 451462-58-1
  • C16H21N3O2S2HCl
  • Angiogenesis and Metastasis
  • Intracellular signaling
  • SiChem
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