DOMOIC ACID
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- CAS-Nr.
- 14277-97-5
- Englisch Name:
- DOMOIC ACID
- Synonyma:
- C13732;Domoic;omoicaci;NSC 288031;DOMOIC ACID;L-Domic acid;(-)-Domic acid;DoMoic Acid-d3;(-)-DoMoic Acid-d3;Domoic acid, 100ppm
- CBNumber:
- CB2359498
- Summenformel:
- C15H21NO6
- Molgewicht:
- 311.33
- MOL-Datei:
- 14277-97-5.mol
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DOMOIC ACID Eigenschaften
- Schmelzpunkt:
- 213-217℃
- Siedepunkt:
- 451.38°C (rough estimate)
- Dichte
- 1.1800 (rough estimate)
- Brechungsindex
- 1.5130 (estimate)
- storage temp.
- -20°C
- L?slichkeit
- methanol: 0.6 mg/mL
- pka
- 2.08±0.60(Predicted)
- Aggregatzustand
- solid
- Farbe
- white
- Optische Aktivit?t
- -109.612 (H2O)
- Wasserl?slichkeit
- Soluble in water at 8mg/ml. Soluble in methanol at 0.6mg/ml.
- Merck
- 13,3451
- BRN
- 46376
- Stabilit?t:
- Light Sensitive
- EPA chemische Informationen
- Domoic acid (14277-97-5)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
20/21/22 |
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| S-S?tze: |
36/37 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
UX9665100 |
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| Giftige Stoffe Daten |
14277-97-5(Hazardous Substances Data) |
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| Toxizit?t |
An excitory
amino acid isolated from the red alga Chondria armata. A structural
analog of kainic acid and domoic acid has been shown to be
responsible for the shellfish poisoning associated with eating certain
cultured blue mussels. |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H370 |
Sch?digt die Organe. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P307+P311, P321,P405, P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P405 |
Unter Verschluss aufbewahren. |
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DOMOIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
Off-White Solid
Verwenden
Labelled Domoic Acid. Domoic Acid is an excitatory amino acid isolated from the red alga Chondria armata Okamura, Rhodomelaceae. Domoic acid shown to be responsible for amnesic shellfish poisoning ass
ociated with ingestion of certain cultured blue mussels. Domoic Acid is a structural analog of Kainic acid (K135000).
Definition
ChEBI: A L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is an analog of kainic acid and is the neurotoxin associated with the a
nesic shellfish poisoning (ASP).
Allgemeine Beschreibung
Domoic acid, a heterocyclic amino acid neurotoxin is synthesized by various marine algaes. It possess some structural similarity to kainic acid.
Biologische Aktivit?t
More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.
l?uterung methode
Domoic acid (~300 mg) is purifed on a Dowex1 column (3.5 x 40 mm, 200-400 mesh, acetate form), washed with H2O until neutral, then eluted with increasing concentrations of AcOH (8L) from 0 to 0.25M. The fraction containing domoic acid (in 50mL) is collected, evaporated to dryness under reduced pressure and recrystallised from aqueous EtOH. It is a glutamate and a Kainate receptor agonist. [Impellizzeri et al. Phytochemistry 14 1549 1975, Takemoto & Diago Arch Pharm 293 627 1960, Beilstein 22/4 V 371.]
DOMOIC ACID Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
DOMOIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 87)Lieferanten
14277-97-5()Verwandte Suche:
- (2S-(2-alpha,3-beta,4-beta(1Z,3E,5S*)))-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic acid
- (-)-Domic acid
- (2S)-2α-Carboxy-4β-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadienyl]-3β-pyrrolidineacetic acid
- L-Domic acid
- 3-Pyrrolidineacetic acid, 2-carboxy-4-(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadienyl-
- C13732
- (2S,3S,4S)-2-Carboxy-4-[(1Z,3E,5R)-5-carboxy-1-Methyl-1,3-hexadien-1-yl]-3-pyrrolidineacetic Acid
- NSC 288031
- (-)-DoMoic Acid-d3
- (2S,3S,4S)-2-Carboxy-4-[(1Z,3E,5R)-5-carboxy-1-Methyl-1,3-hexadien-1-yl]-3-pyrrolidineacetic Acid-d3
- DoMoic Acid-d3
- 2-carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineaceticaci(2s
- DOMOIC ACID
- DOMOIC ACID, MYTILUS EDULIS
- 3-beta,4-beta(1z,3e,5s*)))--(2-alph
- 2S-[2ALPHA, 3BETA, 4BETA (1Z, 3E, 5R)]-2-CARBOXY-4-(5-CARBOXY-1-METHYL-1,3-HEXADIENYL)-3-PYRROLIDINEACETIC ACID
- (2S,3S,4R,5'R)-2-CARBOXY-4-(5'-CARBOXY-1'-METHYL-1Z,3E-HEXADIENYL)-3-PYRROLIDINEACETIC ACID
- Domoic
- 3-Pyrrolidineacetic acid, 2-carboxy-4-(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadienyl-, (2S,3S,4S)-
- AMNESICSHELLFISHPOISON
- AMNESICSHELLFISHPOISONING
- DOMOICACID=DOMOINSRE
- 14277-97-5 DOMOIC ACID
- omoicaci
- Myticus edulis, homogenized (Domoic acid)
- Domoic acid, 100ppm
- 3-Pyrrolidineacetic acid, 2-carboxy-4-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadien-1-yl]-, (2S,3S,4S)-
- Domoic Acid, Mytilus edulis - CAS 14277-97-5 - Calbiochem
- (2S,3S,4S)-4-[(2Z,4E,6R)-6-carboxyhepta-2,4-dien-2-yl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid
- Domoic acid in ACN/H2O
- Myticus edulis, homogenized (Domoic acid) in mussel homogenate
- Buprenorphine Impurity 23
- 14277-97-5
- Biochemicals and Reagents
- BioChemical
- Amino Acids and Peptides
- A - H
- Cell Signaling and Neuroscience
- Cell Biology
- Ligand-Gated Ion Channels
- Modified Amino Acids
- Ion Channels
- Ionotropic Glutamate Receptor Modulators
- Amino Acids & Derivatives
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Glutamate receptor
- AlgaeNeurotransmitters
- AMPA/Kainate AgonistsIon Channels
- Ionotropic Glutamate Receptor Modulators
- Cell Signaling and Neuroscience
- Excitatory Amino Acids
- Ligand-Gated Ion Channels
- Toxins and Venoms
