N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
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N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Eigenschaften
- Siedepunkt:
- 714.8±60.0 °C(Predicted)
- Dichte
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO:100.0(Max Conc. mg/mL);214.3(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);107.15(Max Conc. mM)
- pka
- 15.39±0.46(Predicted)
- Aggregatzustand
- solid
- Farbe
- clear white to light brown
Sicherheit
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor used in pharmacological studies which showed that it underwent metabolic breakdown to RA-7 and showed pharmacological activities such as induced hypothermia in mice and showed optimal pharmacokinetics in rats.LP-211 is also a drug analogue of piperazinehexanamide exhibiting 5-HT7 receptor affinity.Biochem/physiol Actions
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 44)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32159 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24727 | 58 |
TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38630 | 58 |
Aladdin Scientific | |
tp@aladdinsci.com | United States | 52924 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51456 | 80 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 |
China | 4599 | 55 | |
Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 |
3008007409@qq.com | China | 27313 | 60 |
- LP-211
- N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
- LP-211; LP 211; LP211;1052147-86-0
- LP21
- LP-211 >=98% (HPLC)
- LP 211,Inhibitor,5-HT Receptor,Serotonin Receptor,LP-211,5-hydroxytryptamine Receptor,LP211,inhibit
- 1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-
- LP-211, 10 mM in DMSO
- 1052147-86-0
- API