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N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Struktur
1052147-86-0
CAS-Nr.
1052147-86-0
Englisch Name:
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
Synonyma:
LP21;LP-211;LP-211 >=98% (HPLC);LP-211, 10 mM in DMSO;LP-211; LP 211; LP211;1052147-86-0;N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide;1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-;LP 211,Inhibitor,5-HT Receptor,Serotonin Receptor,LP-211,5-hydroxytryptamine Receptor,LP211,inhibit
CBNumber:
CB23385434
Summenformel:
C30H34N4O
Molgewicht:
466.62
MOL-Datei:
1052147-86-0.mol

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Eigenschaften

Siedepunkt:
714.8±60.0 °C(Predicted)
Dichte
1.17±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO:100.0(Max Conc. mg/mL);214.3(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);107.15(Max Conc. mM)
pka
15.39±0.46(Predicted)
Aggregatzustand
solid
Farbe
clear white to light brown

Sicherheit

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor used in pharmacological studies which showed that it underwent metabolic breakdown to RA-7 and showed pharmacological activities such as induced hypothermia in mice and showed optimal pharmacokinetics in rats.LP-211 is also a drug analogue of piperazinehexanamide exhibiting 5-HT7 receptor affinity.

Biochem/physiol Actions

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 42)Lieferanten
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TargetMol Chemicals Inc.
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Sigma-Aldrich 021-61415566 800-8193336
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Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4589 55
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903
 3008007409@qq.com China 27313 60
  • LP-211
  • N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
  • LP-211; LP 211; LP211;1052147-86-0
  • LP21
  • LP-211 >=98% (HPLC)
  • LP 211,Inhibitor,5-HT Receptor,Serotonin Receptor,LP-211,5-hydroxytryptamine Receptor,LP211,inhibit
  • 1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-
  • LP-211, 10 mM in DMSO
  • 1052147-86-0
  • API
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