Glucagon Receptor Antagonist I Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC
50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions.
Glucagon Receptor Antagonist I Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte