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MRT67307

MRT67307 Struktur
1190379-70-4
CAS-Nr.
1190379-70-4
Englisch Name:
MRT67307
Synonyma:
MRT68921(HCI);MRT68921(HCl);MRT68921 (free base);MRT68921;MRT-68921;MRT 68921;N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)prop;N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide;N-(3-((5-cyclopropyl-2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide;Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-;N-(3-((5-Cyclopropyl-2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide , MRT68921
CBNumber:
CB23043299
Summenformel:
C25H34N6O
Molgewicht:
434.58
MOL-Datei:
1190379-70-4.mol

MRT67307 Eigenschaften

storage temp. 
Store at -20°C
L?slichkeit
insoluble in H2O; insoluble in EtOH; ≥2.18 mg/mL in DMSO with gentle warming and ultrasonic
Aggregatzustand
A crystalline solid
Farbe
Light yellow to yellow
Wasserl?slichkeit
H2O: 20mg/mL, clear

Sicherheit

MRT67307 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

MRT68921 is an inhibitor of ULK1 and ULK2 (IC50s = 2.9 and 1.1 nM, respectively). Through its effects on ULK1, MRT68921 blocks autophagy in cells, driving the accumulation of stalled early autophagosomal structures.

Verwenden

MRT68921 dihydrochloride has been used:
  • as a specific inhibitor of Unc-51-like kinase 1 (ULK1) in SH-SY5Y neuroblastoma cells
  • as an inhibitor of ULK1 and ULK2 kinases in intrahepatic lymphocytes
  • as a ULK1 inhibitor to test its effect on attenuation of autophagosome accumulation in ubiquitin-specific peptidase 24 (USP24)?knockdown containing human neuroglioma H4 cells

Biochem/physiol Actions

MRT68921 is cytotoxic and acts on oxidative stress signals to kill cancer cells, making it an effective tumor therapy agent.

MRT67307 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MRT67307 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 46)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32965 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29810 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 24727 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998
 757984502@qq.com China 892 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Shanghai Topbiochem Technology Co., Ltd 021-58170097
info@topbiochem.com China 9478 58
  • MRT68921(HCl)
  • MRT68921(HCI)
  • N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide
  • MRT68921 (free base)
  • Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-
  • N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)prop
  • MRT68921;MRT-68921;MRT 68921
  • N-(3-((5-cyclopropyl-2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide
  • N-(3-((5-Cyclopropyl-2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide , MRT68921
  • 1190379-70-4
  • C25H34N6OxHCl
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