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TAPI-1

TAPI-1 Struktur
171235-71-5
CAS-Nr.
171235-71-5
Englisch Name:
TAPI-1
Synonyma:
TAP 1;CS-1499;(S,S)-TAPI-1;(2S,2S)-TAPI-1;TAPI-1 TFA Salt;2-aminoethyl Amide;TAPI-1 trifluoroacetate;TNF-α Protease Inhibitor-1;TNF-Α PROTEASE INHIBITOR-1 (TAPI-1);N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine
CBNumber:
CB22729657
Summenformel:
C26H37N5O5
Molgewicht:
499.6
MOL-Datei:
171235-71-5.mol

TAPI-1 Eigenschaften

Dichte
1?+-.0.06 g/cm3(Predicted)
storage temp. 
-20C
L?slichkeit
≥24.98 mg/mL in DMSO; ≥15.77 mg/mL in EtOH with ultrasonic; ≥18.1 mg/mL in H2O
Aggregatzustand
White solid
pka
9.17±0.20(Predicted)
Farbe
White to off-white

Sicherheit

TAPI-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α convertase; ADAM17). However, TAPI-1 is more stable in serum than TAPI-0. TAPI-1 Blocks the shedding of several cell surface proteins such as TNF-α, IL-6 receptor, and p60 and p80 TNF receptors. Inhibits constitutive (IC50 = 8.09 μM) and muscarinic receptor-stimulated (IC50 = 3.61 μM) sAPPa release in HEK-293 cells expressing muscarinic receptors. Also blocks the TACE-dependent constitutive release of co-transfected APP(695) (IC50 = 920 nM).

Biochem/physiol Actions

Primary TargetMMPs and TACE

TAPI-1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

TAPI-1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 57)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alpha Biopharmaceuticals Co., Ltd 		+86-15542445688
sales@alabiochem.com China 888 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32951 60
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439
 sales@nextpeptide.com China 19908 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 24727 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38465 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
Alabiochem Tech.Co., Ltd. 0512-58900862 400-0707518
 sales@alabiochem.com China 995 59
  • N1-((S)-1-((S)-1-(2-aminoethylamino)-1-oxopropan-2-ylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide
  • N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide
  • N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide TAPI-1
  • TAPI-1 trifluoroacetate
  • TNF-Α PROTEASE INHIBITOR-1 (TAPI-1)
  • 2-aminoethyl Amide
  • N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine
  • N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE; 2-AMINOETHYL AMIDE; TNF-Α PROTEASE INHIBITOR-1
  • TNF-α Protease Inhibitor-1
  • (2S,2S)-TAPI-1
  • CS-1499
  • TAP 1
  • L-Alaninamide, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)- (9CI)
  • TAPI-1 TFA Salt
  • (S,S)-TAPI-1
  • 171235-71-5
  • C26H37N5O5
  • Inhibitors
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