Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl- Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
LPA
2 antagonist 1 is an antagonist of lysophosphatidic acid receptor 2 (LPA
2; IC
50 = 17 nM). It is selective for LPA
2 over LPA
1 and LPA
3 (IC
50s = >50 μM). LPA
2 antagonist 1 inhibits HGF-induced phosphorylation of ERK and proliferation of HCT116 colon cancer cells in a concentration-dependent manner.
Verwenden
N-[(2S)-1-[4-(3,4-Dichlorophenyl)sulfonylpiperazin-1-yl]propan-2-yl]-7-methylthieno[3,2-d]pyrimidin-4-amine is a Lpa2 protein antagonists.
Thieno[3,2-d]pyriMidin-4-aMine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-Methylethyl]-7-Methyl- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte