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NG-25

NG-25 Struktur
1315355-93-1
CAS-Nr.
1315355-93-1
Englisch Name:
NG-25
Synonyma:
NG25;3-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide;NG-25;NG 25; NG-25;HG-7-92-01 (NG 25);NG-25 ISO 9001：2015 REACH;NG25,MAP kinase kinase kinase, MEKK, MAPKKK,NG 25,NG-25,MAP4K,inhibit,Inhibitor,MAP3K,MAPK Kinase Kinase Kinase;N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide;N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide;Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-
CBNumber:
CB22645146
Summenformel:
C29H30F3N5O2
Molgewicht:
537.58
MOL-Datei:
1315355-93-1.mol

NG-25 Eigenschaften

Dichte
1.313±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
Soluble in DMSO
Aggregatzustand
powder
pka
12.91±0.70(Predicted)
Farbe
white to beige
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
RIDADR  UN 2811 6.1 / PGIII
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H413 Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 4
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.

NG-25 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

NG 25 inhibits TGF-beta-activated kinase 1 (TAK1). It also inhibits LYN, mitogen-activated protein kinase (MAP4K2) and Abl kinase activity.

Biochem/physiol Actions

NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.

NG-25 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

NG-25 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 72)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32820 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 31991 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 23325 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38460 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720
 chaolaichem@foxmail.com China 7879 58

1315355-93-1()Verwandte Suche:

  • N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
  • 3-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3v-(trifluoromethyl)phenyl)-4-methylbenzamide
  • NG-25
  • HG-7-92-01 (NG 25)
  • N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
  • NG 25; NG-25
  • Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-
  • NG-25 ISO 9001：2015 REACH
  • NG25
  • 3-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide
  • NG25,MAP kinase kinase kinase, MEKK, MAPKKK,NG 25,NG-25,MAP4K,inhibit,Inhibitor,MAP3K,MAPK Kinase Kinase Kinase
  • 1315355-93-1
  • C29H30F3N5O2
  • Smad
  • TGF-beta
  • TGF-beta/Smad
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