(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride
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- CAS-Nr.
- 521284-22-0
- Englisch Name:
- (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride
- Synonyma:
- Mirabegron INT 3;Mirabegron Impurity M;Mirabegron Impurity 3 HCl;DarunavirDiamino(2S,3S)Isomer;Mirabegron Impurity 20 Hydrochloride;(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]m;(R)-alpha-[[[2-(4-AMinophenyl)ethyl]aMino]Methyl];(R)-2-(4-aminophenethylamino)-1-
Phenylethanol HCL;(R)-2-[2-(4-Amino-phenyl)-ethylamino]-1-phenyl-ethanol HCl;(R)--[[[2-(4-aminophenyl)ethyl]amino]methyl]-Benzenemethanol
- CBNumber:
- CB22614397
- Summenformel:
- C16H21ClN2O
- Molgewicht:
- 292.81
- MOL-Datei:
- 521284-22-0.mol
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(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride Eigenschaften
- Dichte
- 1145 at 20℃
- Dampfdruck
- 0.015Pa at 25℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Powder
- Stabilit?t:
- Hygroscopic
- LogP
- -1.35 at 20℃ and pH5.79
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Synthese
A mixture of (100 g) (R)-2-[2?ˉ -(4-nitrophenyl)ethyl]amino] -1 -phenylethanol monohydroch bride (prepared according to example Ib), methanol (2000 mL) and Raney Nickel (20 g, wet) was stirred under hydrogen pressure (60 psi) for 6 hrs. The reaction solution was filtered, and the filtrate was concentrated in vacuo. The residue was mixed with isopropanol (300 mL) and reaction mixture was heated to 78??C (?à2). The mixture was added to toluene (900 mL). The reaction mixture was gradually cooled to 28??C (?à2) and stirred at this temperature for 3 hrs. The solid obtained was filtered, washed with toluene and dried under vacuo at 48??C (?à2) to obtain (R)-2-[[2-(4-aminophenyl)ethyl]-amino]- I -phenylethanol monohydrochioride.Yield: 78.1 g (86.1%); Purity by HPLC: 99.14 %.
(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 197)Lieferanten
- (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride
- (R)-alpha-[[[2-(4-AMinophenyl)ethyl]aMino]Methyl]
- (R)-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]- BenzeneMethanol HCl
- (R)--[[[2-(4-aminophenyl)ethyl]amino]methyl]-Benzenemethanol
- Mirabegron INT 3
- (R) -2 - [[2- (4- aminophenyl) ethyl] amino] -1-phenylethanol hydrochloride
- (R)-2-((4-AMinophenethyl)aMino)-1-phenylethanol hydrochloride
- (1R)-2-{[2-(4-Aminophenyl)ethyl]amino}-1-phenylethanol hydrochlor ide (1:1)
- (R)-2-((4-aminophenethyl)amino)-1-phenylethanol hydrochloride (1:1)
- (R)-2-[2-(4-Amino-phenyl)-ethylamino]-1-phenyl-ethanol HCl
- Mirabegron Impurity M
- (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]m
- (αR) -α-[[[[[(2- (4-aminophenyl) ethyl] amino] methyl] benzyl alcohol hydrochloride
- (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride(For export only)
- (R)-2-(4-AMINOPHENETHYL AMINO)-1-PHENYLE THANOL HYDROCHLORIDE / MRG5 HCL
- (R)-2-(4-aminophenethylamino)-1-
Phenylethanol HCL
- (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzen...
- alphaR)-alpha-lI12-(4-Aminophenyl)ethylamino]methylbenzenemethanol
hydrochloride
- 2H-Pyrrol-2-one,1,5-dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(10-pyridinyl)-
- Dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-y/l)phosphonatee'
- Alphar)-alpha-[[[2-(4-minophenyl)ethyl]amino]methyl] benzenemethanol hydrochloride
- Mirabegron Impurity 20 Hydrochloride
- (R) Alpha - [[2- (4-aminophenyl) ethyl] amino] methyl] - benzyl alcohol hydrochloride
- DarunavirDiamino(2S,3S)Isomer
- Mirabegron Impurity 3 HCl
- 521284-22-0
- 521284-22-0
