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MK8245

MK8245 Struktur
1030612-90-8
CAS-Nr.
1030612-90-8
Englisch Name:
MK8245
Synonyma:
CS-1662;]-5-isoxazoL;]-2H-tetrazoL;MK 8245;MK8245;e-2-acetic acid;MK8245 USP/EP/BP;5-[3-[4-(2-Bromo-5-fL;MK8245;MK-8245;MK 8245;uorophenoxy)-1-piperidinyL;5-[3-[4-(2-Bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid
CBNumber:
CB22546432
Summenformel:
C17H16BrFN6O4
Molgewicht:
467.25
MOL-Datei:
1030612-90-8.mol

MK8245 Eigenschaften

Siedepunkt:
698.3±65.0 °C(Predicted)
Dichte
1.82
storage temp. 
Sealed in dry,Store in freezer, under -20°C
L?slichkeit
≥23.35 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
Aggregatzustand
solid
pka
2.85±0.10(Predicted)
Farbe
White to off-white
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H242 Erw?rmung kann Brand verursachen. Organische Peroxide Typen C & D Achtung
Warnung		 GHS hazard pictogramssrc="/GHS02.jpg" width="20" height="20" /> P210, P220, P234, P280, P370+P378,P403+P235, P411, P420, P501
Sicherheit
P210 Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P234 Nur im Originalbeh?lter aufbewahren.
P235 Kühl halten
P240 Beh?lter und zu befüllende Anlage erden.
P370+P378 Bei Brand: zum L?schen verwenden.
P403 An einem gut belüfteten Ort aufbewahren.

MK8245 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD; IC50s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively). It is selective for SCD1 over Δ5- and Δ6-desaturases (IC50s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to stearic acid, a marker of chronic SCD activity, and blood glucose levels, without inducing the formation of skin lesions or eye squinting behavior, in a mouse model of high-fat diet-induced obesity. It also inhibits hepatitis C virus (HCV) replication without inducing cytotoxicity in LucNeo2 cells (IC50 = 39.8 nM).

Verwenden

This product is Informer compound X9 of the Aryl Halide Chemistry Informer Library developed by chemists at Merck & Co., Inc., Kenilworth, NJ, U.S., which contains 18 drug-like molecules representative of those encountered in complex synthesis. By screening a new reaction against the Informer Library, chemists can directly compare and analyse a reaction′s successes and shortcomings among different methods and various research teams. It may also be used to facilitate deeper method development for performance or utility.

MK8245 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazole-5-carbonitrile 3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazole-5-carboxamide tert-butyl2-(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetate 3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)-4,5-dihydroisoxazole-5-carboxamide 4-(2-Bromo-5-fluorophenoxy)-1-[5-(2H-tetrazol-5-yl)-3-isoxazolyl]piperidine Piperidine, 4-(2-bromo-5-fluorophenoxy)- 2-Bromo-5-fluorophenol Piperidin-4-ol N-BOC-4-Hydroxypiperidine 1-Brom-2,4-difluorbenzol Ethyl-bromacetat

Downstream Produkte

MK8245 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 85)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28172 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 22784 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 24727 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
  • 5-[3-[4-(2-Bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid
  • 2-(5-(3-(4-(2-broMo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid
  • MK 8245;MK8245
  • MK8245;MK-8245;MK 8245
  • CS-1662
  • ]-2H-tetrazoL
  • ]-5-isoxazoL
  • 5-[3-[4-(2-Bromo-5-fL
  • e-2-acetic acid
  • uorophenoxy)-1-piperidinyL
  • 2H-Tetrazole-2-acetic acid, 5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-
  • MK8245 USP/EP/BP
  • 2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]aceticaci
  • 1030612-90-8
  • C17H16BrFN6O4
  • Inhibitors
  • Inhibitor
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