AT7867 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
AT7867 is a potent and orally bioavailable inhibitor of Akt isoforms Akt1, 2, and 3 (IC
50s = 32, 17, and 47 nM, respectively). It also inhibits p70S6 kinase and PKA (IC
50s = 85 and 20 nM, respectively), but is without effect against a panel of other kinases. AT7867 inhibits growth and induces apoptosis in a variety of cancer cell lines
in vitro and suppresses tumor growth of PTEN-deficient xenografts in mice.
Verwenden
A potent Akt inhibitor with an IC50 of 17 nM. AT7867 also inhibits structurally related AGC kinases p70S6K and PKA with IC50s of 20 nM and 85 nM, respectively.
Enzyminhibitor
This potent ATP-competitive inhibitor (FW = 337.85; CAS 857531-00-1; Solubility: 68 mg/mL DMSO, <1 mg/mL H2O), known systematically as 4- (4-(1H-pyrazol-4-yl)phenyl)-4-(4-chlorophenyl)piperidine, targets Akt1, Akt2 and Akt3 Protein Kinases B (or PKB), with IC50 values of 32 nM, 17 nM and 47 nM, respectively. AT7867 also inhibits the structurally related AGC kinases, p70S6K and PKA, with IC50 values of 20 nM and 85 nM, respectively.
AT7867 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
