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6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Struktur
64232-83-3
CAS-Nr.
64232-83-3
Englisch Name:
6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
Synonyma:
L189;L 189;L189;(E)-6-amino-5-(benzylideneamino)-2-mercaptopyrimidin-4-ol;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone;6-Amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone;4(1H)-PyriMidinone, 6-aMino-2,3-dihydro-5-[(phenylMethylene)aMino]-2-thioxo-
CBNumber:
CB22518932
Summenformel:
C11H10N4OS
Molgewicht:
246.29
MOL-Datei:
64232-83-3.mol

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Eigenschaften

Schmelzpunkt:
250 °C (decomp)
Dichte
1.45±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
L?slichkeit
≥62.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
Aggregatzustand
solid
pka
8.16±0.60(Predicted)
Farbe
Light yellow to yellow

Sicherheit

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 μM, respectively). It blocks DNA binding (Ki = 5 μM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation. L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.

Verwenden

L189 has been shown to inhibit DNA ligases I, III, and IV and may have potential use in the development of anticancer agents.

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 86)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32951 60
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30241 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574
 info@chemia-pharm.com CHINA 311 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38468 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2922 55
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
  • 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
  • L189
  • 4(1H)-PyriMidinone, 6-aMino-2,3-dihydro-5-[(phenylMethylene)aMino]-2-thioxo-
  • (E)-6-amino-5-(benzylideneamino)-2-mercaptopyrimidin-4-ol
  • 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone
  • L 189;L189
  • 6-Amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
  • 64232-83-3
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