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MF-63

MF-63 Struktur
892549-43-8
CAS-Nr.
892549-43-8
Englisch Name:
MF-63
Synonyma:
MF-63;CS-2773;MF 63; MF-63;2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-Benzenedic;2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile;2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile;2-(9-Chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)benzene-1, 3-dicarbonitrile;1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-
CBNumber:
CB22512521
Summenformel:
C23H11ClN4
Molgewicht:
378.81
MOL-Datei:
892549-43-8.mol

MF-63 Eigenschaften

Siedepunkt:
709.7±70.0 °C(Predicted)
Dichte
1.49
storage temp. 
Store at -20°C
L?slichkeit
Soluble in DMSO
Aggregatzustand
crystalline solid
pka
11.34±0.30(Predicted)
Farbe
Light yellow to yellow

Sicherheit

MF-63 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the terminal enzyme in the biosynthesis of PGE2. MF63 is a potent, selective, and orally active inhibitor of human mPGES-1 (IC50 = 1.3 nM). It displays greater than 1,000-fold selectivity over other prostanoid synthases. MF63 also potently inhibits guinea pig mPGES-1 (IC50 = 0.9 nM) but not mouse or rat mPGES-1. In guinea pigs or in mice expressing human mPGES-1, MF63 prevents LPS-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain. It does not produce the gastrointestinal toxicity that is caused by non-selective COX inhibitors, although it markedly suppresses PGE2 synthesis in the stomach.

Verwenden

MF 63 is a microsomal prostaglandin E2 synthase-1 (mPGES-1) the final enzyme in the synthesis of PGE2. Prevents LPS-induced hyperglasia. Anti-inflammatory, analgesic, anti-cancer agent.

MF-63 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MF-63 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 83)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32072 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501
 product@acmec-e.com China 33338 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52925 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580
 cooperation@kean-chem.com China 40066 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
Chembest Research Laboratories Limited +86-21-20908456
sales@BioChemBest.com China 6005 61
  • MF-63
  • 2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile
  • 2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile
  • 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-Benzenedic
  • MF 63; MF-63
  • CS-2773
  • 1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-
  • 2-(9-Chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)benzene-1, 3-dicarbonitrile
  • 892549-43-8
  • C23H11ClN4
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