(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride
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- CAS-Nr.
- 1156491-10-9
- Englisch Name:
- (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride
- Synonyma:
- (1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride;(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1);(1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride;Ticagrelor USP RC A;Ticagrelor side chain 2 hydrochloride;2-(3,4-Difluoro-phenyl)-cyclopropylamine;(1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami;(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine HCl
- CBNumber:
- CB22498775
- Summenformel:
- C9H10ClF2N
- Molgewicht:
- 205.63
- MOL-Datei:
- 1156491-10-9.mol
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(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Eigenschaften
- Schmelzpunkt:
- >172°C (dec.)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White
- InChI
- InChI=1/C9H9F2N.ClH/c10-7-2-1-5(3-8(7)11)6-4-9(6)12;/h1-3,6,9H,4,12H2;1H/t6-,9+;/s3
- InChIKey
- IMYLOCHFFLYHPS-RHUSADAZNA-N
- SMILES
- N[C@@H]1C[C@H]1C1C=CC(F)=C(F)C=1.Cl |&1:1,3,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
1,2-Difluorobenzene is reacted with 3-chloropropionyl chloride to
produce 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one, which is by
addition of N,N-dimethylformamide,
phloroglucinol and sodium iodide in the next step converted to
1-(3',4'-difluorophenyl)-3-nitro-propan-1-one. The keto group of the
latter intermediate is in the subsequent step stereochemically reduced
to hydroxyl group by the use of chiral oxazaborolidine together with
borane dimethyl sulfide or borane-N,N-diethyl aniline complex in the presence of tetrahydrofurane. The obtained (1R)-1-(3',4'-difluorophenyl)-3-nitro-propan-1-ol
is then added to a mixture of triphenylphosphine and
diethylazodicarboxylate in benzene to yield (1S,2R)-2-(3',4'-difluorophenyl)-1-nitrocyclopropane, which is in the last step converted to 2-(3,4-difluorophenyl)cyclopropane amine by reduction of the nitro group by catalytic hydrogenation with palladium catalyst and zink dust.
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 265)Lieferanten
- (1R,2S)-2-(3,4-Difluorophenyl)-cyclopropan-1-aMine HCL
- (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami
- 2-(3,4-Difluoro-phenyl)-cyclopropylamine
- (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
- CYCLOPROPANAMINE, 2-(3,4-DIFLUOROPHENYL)-, HYDROCHLORIDE (1:1), (1R,2S)-REL-
- trans-(1R,2S)-2-(3,4-difluorphenyl)cyclopropylaMine
- (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine HCl
- (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochlorideQ: What is
(1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride Q: What is the CAS Number of
(1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride Q: What is the storage condition of
(1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride
- (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine hydrochl...
- (1R,2S)-REL-2-(3,4-difluorophenyl)cyclopropane amine chloride
- Ticagrelor side chain 2 hydrochloride
- trans-rel-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride
- Ticagrelor USP RC A
- trans-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride
- (1R,2S)-2-(3,4-difluorophenyl)cyclopropane amine hydrochloride
- trans-(1R,2S)-2-(3,4-Diflurophenyl)cyclopropylamine hydrochloride
- (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine HCl
- (1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1)
- (1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride
- (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
- (1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine
- (1R,2S)-2-(3,4-Diflurophenyl)cyclopropylamine hydrochloride,
- (1R,2S)-rel-2-(3,4-Difluorophenyl)-cyclopropanamine hydrochloride (1:1)
- (1R, 2S) - REL-2- (3,4-difluorophenyl) cyclopropylamine hydrochloride
- 1R trans)-2-(3,4-difluorophenyl)cyclopropane amine in stock
- (1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo
- (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochlo
- trans)-2-(3,4-difluorophenyl)cyclopropane amine hydrochloride
- (1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine hydrochloride
- (1R,2S)-Rel-2-(3,4-Difluorophenyl)-Cyclopropanamine Hydr
- 1156491-10-9
- C9H9F2NHCl
- Intermediate of Ticagrelor
- 1156491-10-9
