Proxymetacainhydrochlorid
|
|
Proxymetacainhydrochlorid Eigenschaften
- Schmelzpunkt:
- 182.0-183.3°
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- Chloroform (Slightly), Methanol, Water
- Aggregatzustand
- Solid
- pka
- 3.2(at 25℃)
- Farbe
- White to Off-White
- maximale Wellenl?nge (λmax)
- 300nm(MeOH)(lit.)
- Merck
- 14,7807
- InChI
- InChI=1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H
- InChIKey
- BFUUJUGQJUTPAF-UHFFFAOYSA-N
- SMILES
- C(OCCN(CC)CC)(=O)C1=CC=C(OCCC)C(N)=C1.[H]Cl
- CAS Datenbank
- 5875-06-9(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xn | ||
---|---|---|---|
R-S?tze: | 20/21/22-36-43 | ||
S-S?tze: | 26-36 | ||
WGK Germany | 3 | ||
RTECS-Nr. | DG3065000 | ||
HS Code | 2922504500 |
Bildanzeige (GHS) | ||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alarmwort | Warnung | |||||||||||||||||||||
Gefahrenhinweise |
|
|||||||||||||||||||||
Sicherheit |
|
Proxymetacainhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.R36:Reizt die Augen.
R43:Sensibilisierung durch Hautkontakt m?glich.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.Verwenden
Topical anesthetic (ophthalmic); Neuronal conductance inhibitor.Trademarks
Alcaine (Alcon); Ophthetic (Allergan); Paracaine (Optopics).Clinical Use
Proparacaine Hydrochloride Ophthalmic Solution is indicated for topical anesthesia in ophthalmic practice.Nebenwirkungen
Occasional temporary stinging, burning and conjunctival redness may occur with the use of proparacaine. A rare, severe, immediate-type, apparently hyperallergic corneal reaction characterized by acute, intense and diffuse epithelial keratitis, a gray, ground glass appearance, sloughing of large areas of necrotic epithelium, corneal filaments and sometimes iritis with descemetitis has been reported. Allergic contact dermatitis from proparacaine with drying and fissuring of the fingertips has been reported.Mode of action
The mechanism of action of proparacaine hydrochloride is to reduce the instantaneous permeability of neurons to sodium, stabilize the nerve cell membrane, and prevent the generation and conduction of nerve electrical impulses, thereby producing anesthesia.Likely inhibits epithelial voltage gated sodium channels like other local anesthetics.Einzelnachweise
1. Identification, synthesis and structural confirmation of process-related impurities in proparacaine hydrochloride. DOI:10.1016/j.jpba.2020.1134972. https://pi.bausch.com/globalassets/pdf/PackageInserts/Pharma/Rx-Generics/Proparacaine-HCl-Ophthalmic-Solution.pdf
3. Imming P., Sinning C., Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct; 5(10):821-34. DOI:10.1038/nrd2132
4. T., Levent T., Inci M.A. Toxic keratopathy associated with abuse of topical anesthetics and amniotic membrane transplantation for treatment. Int J Ophthalmol. 2015; 8(5): 938–944. DOI:10.3980/j.issn.2222-3959.2015.05.15
5. Proparacaine Hydrochloride Topical Drop and Intracameral 0.5% Lignocaine for Phacotrabeculectomy in Patients with Primary Open Angle Glaucoma DOI:10.4103/0974-9233.134669
6. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=447a2a64-0507-4fe8-bb44-cc36c3916151&type=display
Proxymetacainhydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Proxymetacainhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 199)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hebei Zhanyao Biotechnology Co. Ltd | 15369953316 +8615369953316 |
admin@zhanyaobio.com | China | 2123 | 58 |
Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 |
sales@chembj.net | China | 289 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12834 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5889 | 58 |
Hebei Dangtong Import and export Co LTD | +86-86-4001020630 +8619831957301 |
admin@hbdangtong.com | China | 1000 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 |
admin@firsky-cn.com | China | 427 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2472 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 997 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 615 | 58 |
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 |
sales@sjar-tech.com | China | 456 | 58 |
5875-06-9(Proxymetacainhydrochlorid)Verwandte Suche:
Propanthelin
Denatoniumbenzoat
Glycin
Methoxyammoniumchlorid
Carbazamidinmonohydrochlorid
Levomepromazinhydrochlorid
4-Aminobenzoesure
Aminocapronsure
Natriumbenzoat
5H-Dibenz(b,f)azepin-5-propanamin, 10,11-dihydro-N,N-dimethyl-monohydrochlorid
4-Dimethylaminobenzoesure
ALTRENOGEST
Topotecan hydrochloride
Ciprofloxacin hydrochloride
Pyridiniumchlorid
Aminoacetonitrilhydrochlorid
Emamectin benzoate
Triethylammoniumchlorid
- 2-[(3-amino-4-propoxyphenyl)-oxomethoxy]ethyl-diethylammonium chloride
- PROPARACAINE HCL
- PROPARACAINE HYDROCHLORIDE
- 3-amino-4-propoxybenzoicacid2-(diethylamino)ethylesterhydrochloride
- alcaine
- benzoicacid,3-amino-4-propoxy-,2-(diethylamino)ethylester,hydrochloride
- benzoicacid,3-amino-4-propoxy-,2-(diethylamino)ethylester,monohydrochlorid
- beta-(diethylamino)ethyl3-amino-4-n-propoxybenzoatehydrochloride
- chibro-heracaine
- keracaine
- ophthain
- ophthainehydrochloride
- ophthetic
- Proparacaine hydrochloride, >=99%
- 2-diethylaminoethyl 3-amino-4-propoxy-benzoate hydrochloride
- ProxymetacaineHCL2-CHLORO-9-(2'-DEOXY-2'-FLUORO-B-D-ARABINOFURANOSYL)ADENINE
- PROXYMETACAINE(2-DIETHYLAMINOETHYL-3-AMINO-4-PROPOXYBENZOATE HYDROCHLORIDE)
- PROXYMETACAINEHYDROCHLORIDE/PROPARACAINE
- Proparacaine Hydrochloride (200 mg)
- 3-amino-4-propoxy-benzoic acid-2-(diethylamino)ethyl ester, hydrochloride (1:1)
- Proparacaine hydrochloride 2-Diethylaminoethyl 3-amino-4-propoxy-benzoate hydrochloride
- 2-(3-amino-4-propoxy-benzoyl)oxyethyl-diethyl-ammonium chloride
- 2-(3-amino-4-propoxybenzoyl)oxyethyl-diethylazanium chloride
- 2-(3-amino-4-propoxy-phenyl)carbonyloxyethyl-diethyl-azanium chloride
- 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate monohydrochloride
- IN STOCK PROPARACAINE HYDROCHLORIDE CAS 5875-06-9
- ProparacaineHydrochloride>
- Proparacaine HydrochL
- Proparacaine hydrochloride USP/EP/BP
- Proparacaine hydrochloride Reference Substance
- 5875-06-9 Proparacaine hydrochloride
- Proparacaine Hydrochloride (1571001)
- Proparacaine HCI
- Proparacaine Hydrochloride, ≥ 98.0%
- Proparacaine HCl|||Proxymetacaine Hydrochloride
- 5875-06-9
- 5875-6-9
- C16H26N2O3HCl
- Topical ophthalmic anesthetic
- Analytical Standards
- Analytical Chromatography Product Catalog
- PON - PT
- Alphabetic