Cinobufagin
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Cinobufagin Eigenschaften
- Schmelzpunkt:
- 133 °C(lit.)
- Siedepunkt:
- 300 °C(lit.)
- Dichte
- 1.261 g/cm3
- Flammpunkt:
- >230 °F
- storage temp.
- 2-8°C
- L?slichkeit
- DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
- Aggregatzustand
- powder to crystal
- pka
- 15.10±0.70(Predicted)
- Farbe
- White to Light yellow
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xi,T+,Xn | ||
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R-S?tze: | 36/37/38-26/27/28-42/43-20/22 | ||
S-S?tze: | 26-36-45-36/37/39-22-24/25 | ||
RIDADR | UN 2811 6.1/PG 1 | ||
WGK Germany | 3 | ||
RTECS-Nr. | GD7850000 | ||
HazardClass | 6.1(a) | ||
PackingGroup | II | ||
HS Code | 29322090 |
Bildanzeige (GHS) | |||||||||||||||||||||||||||||
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Alarmwort | Achtung | ||||||||||||||||||||||||||||
Gefahrenhinweise |
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Sicherheit |
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Cinobufagin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
R20/22:Gesundheitssch?dlich beim Einatmen und Verschlucken.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Beschreibung
Cinobufagin is a cardiotonic steroid that has been found in the skin of toads of genus Bufo and has diverse biological activities. It inhibits Na+/K+-ATPase activity in guinea pig heart ventricular muscle homogenates by 45% when used at a concentration of 0.3 μM. Cinobufagin is cytotoxic to HCT116 colorectal cancer cells in vitro with IC50 values of less than 50 ng/ml at 48- and 72-hour time points and induces apoptosis in a concentration-dependent manner. In vivo, cinobufagin (10 mg/kg) reduces tumor growth in an HCT116 mouse xenograft model. Cinobufagin (1 μg/ml) inhibits LPS-induced expression of MHC class II, CD80, and CD86 and release of IL-6, IL-8, TNF-α, and IL-10 in human monocyte-derived dendritic cells. It also increases expression of the antimicrobial peptides hBD2 and hBD3 in dendritic cells. Cinobufagin exhibits dose-dependent antinociceptive effects in the hot-plate, acetic acid writhing, and formalin tests in mice.Verwenden
Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.Cinobufagin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Cinobufagin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 230)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 |
1059@dideu.com | China | 3003 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3619 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29879 | 58 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3772 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22963 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39894 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
470-37-1()Verwandte Suche:
Ethylacetat
CELLULOSE ACETATE
Ammoniumacetat
Glatiramer acetate
Vinylacetat
POLY(VINYL ACETATE)
Natriumacetat
2-Cyclohexylethylacetat
Diisopentylether
trans-2,3-Dimethyloxiran
5,6-Epoxyhex-1-en
2-Methyl-6-methylenoct-7-en-2-ol
ACETATE
3-[2-(Dimethylamino)ethyl]-1H-indol-5-ol
Cinobufagin
- RARECHEM BK HC T302
- 5b,20(22)-Bufadienolide-3b,16b-diol-14,15b-epoxy 16-acetate
- CINOBUFAGIN95%,99%
- CINOBUFAGIN(P)
- TRANS-3-PHENYLPROPENOIC ACID
- TRANS-3-BENZENEPROPENOIC ACID
- TRANS-CINNAMYLIC ACID
- Cinobufagin std.
- 16β-Acetoxy-14,15β-epoxy-3β-hydroxy-5β-bufa-20,22-dienolide
- 16β-Acetyloxy-14,15β-epoxy-3β-hydroxy-5β-bufa-20,22-dienolide
- 14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate
- 5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate
- 5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate, 14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate
- Cinobufogenin,Cinobufagin
- 5-((1R,2R,2aR,3aS,3bR,5aR,7S,9aS,9bS,11aR)-2-Acetyl-7-hydroxy-9a,11a-diMethylhexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-1-yl)-2H-pyran-2-one
- 16-beta)-bet
- 22-dienolide,16-(acetyloxy)-14,15-epoxy-3-hydroxy-,(3-beta,5-beta,15-bufa-2
- cinobufagine
- AKOS B004228
- AKOS 233-01
- 3-STYRYLACRYLIC ACID
- 3-PHENYLACRYLIC ACID
- 5BETA,20[22]-BUFADIENOLIDE-3BETA,16BETA-DIOL-14,15BETA-EPOXY 16-ACETATE
- 2-PROPENOIC ACID, 3-PHENYL-, (2E)-
- 14,15BETA-EPOXY-3BETA,16BETA-DIHYDROXY-5BETA,20[22]-BUFADIENOLIDE 16-ACETATE
- BETA-PHENYLACRYLIC ACID
- FEMA 2288
- CINNAMIC ACID, TRANS-
- CINOBUFAGIN
- cinobufagin venom toad
- Cinobufagin, 98%, from cinobufagin venom toad
- Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3-hydroxy-, (3β,5β,15β,16β)-
- Cinobufagin (Cinobufagine)
- Cinobufagin (6CI)
- (1R,2R,2aR,3aS,3bR,5aR,7S,9aS,9bS,11aR)-7-Hydroxy-9a,11a-dimethyl-1-(2-oxo-2H-pyran-5-yl)hexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-2-yl acetate
- Chinese bufotoxin
- (1R,2R,2aR,3aS,3bR,5aR,7S,9aS,9bS,11aR)-7-Hydroxy-9a,11a-dimethyl-1-(2-oxo-2H-pyran-5-yl)hexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-2-yl acetate
- Cinobufagin-RM
- Cinobufagin, 10 mM in DMSO
- 470-37-1
- C26H34O6
- C26H34O6nH2O
- Proteomics and Protein Expression
- Protein Analysis
- Organic Building Blocks
- Matrices for MALDI Analysis
- Auxins
- Mass Spectrometry
- Matrix Materials (MALDI-TOF-MS)
- Plant Growth Regulators
- BioChemical
- Building Blocks
- C9
- Carbonyl Compounds
- Carboxylic Acids
- chemical reagent
- pharmaceutical intermediate
- phytochemical