TETRODOTOXIN CITRATE
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- CAS-Nr.
- 18660-81-6
- Englisch Name:
- TETRODOTOXIN CITRATE
- Synonyma:
- TETRODOTOXIN CITRATE;citratodetetrodotoxina;tetrodotoxin,citrate(1:1)(salt);Tetrodotoxin(TTX), with citrate;Citrato de tetrodotoxina [spanish];Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci);Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat;OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE;(5R,6R,7S,9R,11R,12R,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 2-hydroxypropane-1,2,3-tricarboxylate (1:1) (non-preferred name)
- CBNumber:
- CB2192024
- Summenformel:
- C17H25N3O15
- Molgewicht:
- 511.39
- MOL-Datei:
- 18660-81-6.mol
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TETRODOTOXIN CITRATE Eigenschaften
- storage temp.
- Desiccate at -20°C
- L?slichkeit
- Citrate Buffer (pH 4.8): 30 mg/ml (100 mM)
- Aggregatzustand
- A solid
- pka
- 8.76(at 25℃)
- Wasserl?slichkeit
- Soluble to 100 mM in water
- Stabilit?t:
- Unstable in Acidic solution, Unstable In Acidic Solution
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T+ |
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| R-S?tze: |
26/27/28 |
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| S-S?tze: |
22-36/37/39-45 |
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| RTECS-Nr. |
IO1450000 |
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| Toxizit?t |
A toxin
contained in the ovary and liver of puffer fish, in the eggs of
the California newt and in some other animals. It is used as a
chemical tool for the study of ion channels. The s.c. LD50 in
mice is 10 mg/kg. It is a toxicant of nerve and muscle by
blocking sodium channels, this action causing nerve and muscle paralysis. Symptoms include weakening of voluntary muscles, respiratory failure from paralysis of the diaphragm and
hypotension. There is no antidote. Therapy involves artificial
respiration. |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H300 |
Lebensgefahr bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
| H310 |
Lebensgefahr bei Hautkontakt. |
Acute toxicity,dermal |
Category 1, 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501 |
| H330 |
Lebensgefahr bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P262 |
Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P284 |
Atemschutz tragen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P310 |
Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen. |
| P320 |
Besondere Behandlung dringend erforderlich |
| P321 |
Besondere Behandlung |
| P330 |
Mund ausspülen. |
| P403+P233 |
An einem gut belüfteten Ort aufbewahren. Beh?lter dicht verschlossen halten. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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TETRODOTOXIN CITRATE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
TTX is a potent marine-
derived neurotoxin that reversibly inhibits the inward sodium current through voltage-
activated sodium (Na
v) channels, blocking nerve and muscle action potentials. It inhibits the Na
v current in frog muscle and squid axon with IC
50 values of 4.1 and 5.2 nM, respectively, and binds to rat brain membranes with a K
d value of 1.8 nM. TTX was used in Hodgkin and Huxley’s classic experiments to elucidate the physical biology of nerve action potentials and remains an indispensible neuroscience tool to pharmacologically dissect the contribution of the Na
v current in excitable neurons and to rationally design compounds for the treatment of neuropathic pain. This citrate-
stabilized form of TTX is designed for improved solubility over pure TTX , which is insoluble in water and most organic solvents. This preparation of TTX citrate consists of TTX that has been dissolved in a citrate solution and then lyophilized.
Biologische Aktivit?t
Highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin.
TETRODOTOXIN CITRATE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
TETRODOTOXIN CITRATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 44)Lieferanten
18660-81-6()Verwandte Suche:
- TETRODOTOXIN CITRATE
- OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE
- citratodetetrodotoxina
- tetrodotoxin,citrate(1:1)(salt)
- Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat
- Citrato de tetrodotoxina [spanish]
- Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci)
- Tetrodotoxin(TTX), with citrate
- (5R,6R,7S,9R,11R,12R,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 2-hydroxypropane-1,2,3-tricarboxylate (1:1) (non-preferred name)
- 18660-81-6
- C11H17N3O8C6H8O7
- C17H25N3O15
- Sodium channel
