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W-7 HYDROCHLORIDE

W-7 HYDROCHLORIDE Struktur
61714-27-0
CAS-Nr.
61714-27-0
Englisch Name:
W-7 HYDROCHLORIDE
Synonyma:
W-7;SKL179;CS-1064;ulfonaMide;W-7 HYDROCHLORIDE;OMEGA-7 HYDROCHLORIDE;W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL;6-[(5-chloro-1-naphthalenyl)sulfonylamino]hexylammonium
CBNumber:
CB2182197
Summenformel:
C16H22Cl2N2O2S
Molgewicht:
377.33
MOL-Datei:
61714-27-0.mol

W-7 HYDROCHLORIDE Eigenschaften

Schmelzpunkt:
220-222 °C
storage temp. 
-20°C
L?slichkeit
methanol: 25 mg/mL, clear, colorless
Aggregatzustand
Off-white crystalline solid
Farbe
White to Off-White
BRN 
6030174
CAS Datenbank
61714-27-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gef?hrlicher Xi
S-S?tze: 22-24/25
WGK Germany  3
RTECS-Nr. QK0786000
3-10
HS Code  2935909099

W-7 HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. W-7 is a cell-permeable antagonist of calmodulin (Ki = 11 μM). Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins. W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (Ki = 70 and 300 μM, respectively).

Chemische Eigenschaften

White Crystalline Solid

Verwenden

W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities.

Allgemeine Beschreibung

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 μM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM).

Biologische Aktivit?t

Calmodulin antagonist. Inhibits Ca 2+ -calmodulin-dependent phosphodiesterase (IC 50 = 28 μ M) and myosin light chain kinase (IC 50 = 51 μ M).

W-7 HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


W-7 HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 131)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32072 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30241 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49734 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 49979 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Compound Net Biotechnology Inc.
+8615303909093
sales@compound-net.com China 2914 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
Mainchem Co., Ltd. +86-0592-6210733
sale@mainchem.com China 32343 55

61714-27-0()Verwandte Suche:


  • OMEGA-7 HYDROCHLORIDE
  • N-(6-AMINOHEXYL)-5-CHLORONAPHTHALENE-1-SULFONAMIDE HYDROCHLORIDE
  • N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL
  • N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
  • N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULPHONAMIDE HYDROCHLORIDE
  • W-7
  • W-7 HYDROCHLORIDE
  • N-(6-Aminohexyl)-5-chloronaphthalene-1-sulphonamide hydrochloride
  • 1-Naphthalenesulfonamide, N-(6-aminohexyl)-5-chloro-, monohydrochloride
  • N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide monohydrochloride
  • N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE
  • N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride,W-7
  • ulfonaMide
  • W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem
  • CS-1064
  • 6-[(5-chloro-1-naphthalenyl)sulfonylamino]hexylammonium
  • N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride >
  • SKL179
  • 6-{[(5-chloronaphthalen-1-yl)sulfonyl]amino}hexan-1-aminium
  • Inhibitor,Phosphodiesterase (PDE),anti-proliferation,Calcium-modulated protein,light,chain,Apoptosis,W7 hydrochloride,W 7 hydrochloride,W 7,Ca2+,Calmodulin,W-7,inhibit,CaM,phosphodiesterase,Myosin,phosphate,antitumor
  • 61714-27-0
  • C16H21ClN2O2SClH
  • Antibiotics
  • Antibiotics A to Z
  • Antibiotics A-F
  • BioChemical
  • All Inhibitors
  • Inhibitors
  • Protein Kinase Inhibitors and Activators
  • Calcium signaling
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