COP-1
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Sicherheit
WGK Germany | 3 |
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COP-1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Copaxone was launched in Israel and the US for treatment of relapsingremitting multiple sclerosis. The amino acid polymer is prepared from the Ncarboxyanhydrides of Tyr, Ala, γ-benzylglutamate and ε,N-trifluoroacetyllysine followed by deprotection. Structurally, the random polymer, with a residue molar ratio of 6.0:1.9:4.7:1.O=Ala:Glu:Lys:Tyr, simulates myelin basic protein (MBP). This gives it immunomodulating and immunosuppressive activity (antigen specific so not a general immunosuppressive). The mechanism involves binding to MHC class Ⅱ (I-A/DR) molecules which results both in competition with myelin antigens for T-cell activation and in induction of specific suppressor cells of the Th2 type. Therefore, the antigenspecific interaction gives rise to a reduced probability of long-term damage to the immune system. The competition with MBP and other myelin-associated antigens inhibits T-cell responses to MBP, and the binding occurs with high efficiency, fast rates and is non-species specific. It resulted in a 29% reduction in relapse rate and is most effective in patients with less accumulated neurologic disability.Originator
Yeda (Israel)Trademarks
CopaxoneCOP-1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
COP-1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 18)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Protheragen-ING | +16313385890 |
info@protheragen-ing.com | United States | 3868 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52924 | 58 |
DONBOO AMINO ACID COMPANY | +8613063595538 |
donboo@donboo.com | China | 9363 | 58 |
Nanjing Peptide Biotech Ltd. | 025-025-58361106-805-805 13082558573 |
liugang@njpeptide.com | China | 9980 | 55 |
Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44918 | 58 |
Guangzhou Yunmen Biotechnology Co., Ltd | 18902340307 18902340307 |
3356812514@qq.com | China | 9244 | 58 |
Nanjing Yuanpeptide Biotech Co.,Ltd. | 18168071971 |
support@yuan-peptide.com | China | 2981 | 58 |
HUBEI HICKS BIOCHEMICAL CO.,LTD | 18696113233 |
15927219311@163.com | China | 1614 | 58 |
Hubei Hicks Biochemical Co., Ltd | 17362916295; 17362916295 |
w17362916295@163.com | China | 4000 | 58 |
Zhejiang Jiekun Biotechnology Co., Ltd | 0571-88211951 13735575465 |
sales1@gotopbio.com | China | 4904 | 58 |
28704-27-0()Verwandte Suche:
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- [L-ALA, L-GLU, L-LYS HBR, L-TYR]N
- COP-1
- POLY(ALA, GLU, LYS, TYR) HYDROBROMIDE
- (t,g)-a-l
- poly(ala
- POLY(ALA, GLU, LYS, TYR) 6:2:5:1*HYDROBR OMIDE MOL.
- Copaxone
- (l-ala, l-glu, l-lys, l-tyr)n ·hbr
- poly(ala, glu, lys, tyr) 6:2:5:1 hydrobromide
- poly(alanine-glutamic acid-lysine-tyrosine)
- COP-1, (L-Ala, L-Glu, L-Lys, L-Tyr)n HBr
- Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000
- 28704-27-0
- C3H5NOnH2O
- Polyamino Acids
- Random Copolymers
- Biochemicals and Reagents
- Amino Acids and Peptides
- BioChemical