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Selegiline

Selegiline Struktur
14611-51-9
CAS-Nr.
14611-51-9
Englisch Name:
Selegiline
Synonyma:
SELEGILINE;Emsam;SELEGILINE BASE;BenzeneethanaMine, N,a-diMethyl-N-2-propyn-1-yl-, (aR)-;C07245;Selgene;Zelapar;Selegina;SELEGELIN;Emsam TTS
CBNumber:
CB2137450
Summenformel:
C13H17N
Molgewicht:
187.28
MOL-Datei:
14611-51-9.mol

Selegiline Eigenschaften

Schmelzpunkt:
137.5-139 °C
Siedepunkt:
273℃
alpha 
D20 -11.2°
Dichte
0.954
Brechungsindex
nD20 1.5180
Flammpunkt:
108℃
storage temp. 
-20°C
pka
7.53±0.50(Predicted)
InChI
InChI=1/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/s3
InChIKey
MEZLKOACVSPNER-PLAQIDKDNA-N
SMILES
C1(C=CC=CC=1)C[C@@H](C)N(C)CC#C |&1:7,r|
CAS Datenbank
14611-51-9
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher F,T
R-S?tze: 11-23/24/25-39/23/24/25
S-S?tze: 7-16-36/37-45
RIDADR  1851
WGK Germany  1
HazardClass  6.1(b)
PackingGroup  III
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung GHS hazard pictogramssrc="/GHS02.jpg" width="20" height="20" /> P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Sch?digt die Organe. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P210 Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P311 GIFTINFORMATIONSZENTRUM/Arzt anrufen.

Selegiline Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

This drug is a selective inhibitor of monoaminooxidase B, which suppresses dopamineinactivation processes and facilitates an increase of its level in the brain. In treating Parkinsonism, selegiline is usually used in combination with levodopa.

Weltgesundheitsorganisation (WHO)

Selegiline was introduced in the early 1990s. It is a monoamine oxidase inhibitor and is used in the management of Parkinson's disease. A symptomatic effect of selegiline in Parkinson's disease has been shown, but longer follow-up failed to provide any definitive evidence of ability to retard the loss of dopaminergic neurons (Parkinson's Study Group, 1993).

Biologische Funktion

Another drug used in the treatment of Parkinson’s disease is selegiline (also known as deprenyl, or Eldepryl). It is an irreversible inhibitor of MAO-B, an important enzyme in the metabolism of dopamine (Fig. 33.2). Blockade of dopamine metabolism makes more dopamine available for stimulation of its receptors. Selegiline, as monotherapy, may be effective in the newly diagnosed patient with parkinsonism because its pharmacological effect enhances the actions of endogenous dopamine.
Selegiline is also used in conjunction with levodopa– carbidopa in later-stage parkinsonism to reduce levodopa dosage requirements and to minimize or delay the onset of dyskinesias and motor fluctuations that usually accompany long-term treatment with levodopa. It has also been proposed that selegiline may slow the progression of the disease by reducing the formation of toxic free radicals produced during the metabolism of dopamine. However, any neuroprotective effect of selegiline in parkinsonian patients remains to be established.
Most of the adverse reactions to selegiline are related to actions of increased levels of dopamine, as discussed earlier. At recommended doses, and unlike the nonselective MAO inhibitors used in the treatment of depression, selegiline has little effect on MAO-A and therefore generally does not cause the hypertension associated with the ingestion of tyramine-enriched foods. However, at doses higher than those usually recommended, MAO-A may be inhibited, which increases the risk of a tyramine reaction.
Selegiline should not be coadministered with tricyclic antidepressants or selective serotonin uptake inhibitors because of the possibility of a severe adverse drug reaction (e.g., hyperpyrexia, agitation, delirium, coma).

Selegiline Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Selegiline Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 45)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Qianyi New Material Co., Ltd.
+8618083322317
3391883138@qq.com China 878 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
Xi'an MC Biotech, Co., Ltd.
029-89275612 +8618991951683
mcbio_sales@163.com China 2251 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5975 58
Golden Pharma Co., Limited
+undefined18958062155
sales@zjgoldpharm.com China 5899 58
Wuhan Han Sheng New Material Technology Co.,Ltd
+8617798174412
admin01@hsnm.com.cn China 2097 58
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
Shenzhen Pharma Technology Co., Ltd. 0755-86648230
pharma08@sina.com China 166 58

14611-51-9()Verwandte Suche:


  • dl-Depreny
  • phenylisopropyl-n-MethylpropinylaMine
  • R(-)-Selegiline solution
  • SELEGELIN
  • SELEGILINE
  • R(-)-SELEGILINE
  • N-(Methyl-d3),a-methyl-N-2-propyn-1-yl-benzeneethanamine
  • N-(Methyl-d3),a-methyl-N-2-propynyl Phenethylamine
  • SELEGILINEHYDROCHLORDE
  • (R)-(-)-Deprenyl
  • Benzeneethanamine, N,a-dimethyl-N-2-propynyl-, (aR)- (9CI)
  • Benzeneethanamine, N,a-dimethyl-N-2-propynyl-, (R)-
  • l-Deprenyl
  • Phenethylamine, N,a-dimethyl-N-2-propynyl-, L-(-)- (8CI)
  • (αR)-N,α-Dimethyl-N-(2-propynyl)benzeneethanamine
  • N-Methyl-N-[(R)-1-benzylethyl]-2-propyne-1-amine
  • C07245
  • (R)-N,alpha-Dimethyl-N-2-propynylbenzeneethanamine
  • Emsam TTS
  • Selegina
  • Selgene
  • Zelapar
  • (-)-DEPRENYL
  • (2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine
  • Selegiline hydrochloride CRS
  • (RS)-Selegiline hydrochloride CRS
  • Benzeneethanamine, N,α-dimethyl-N-2-propyn-1-yl-, (αR)-
  • SELEGILINE USP/EP/BP
  • (-)-selegiline
  • (-)-Deprenyl
  • SELEGILINE BASE
  • BenzeneethanaMine, N,a-diMethyl-N-2-propyn-1-yl-, (aR)-
  • Emsam
  • Ethanol,2,2'-[1,5-naphthalenediylbis(oxy-2,5-ethanediyloxy)]bis-
  • SELEGILINE
  • SELEGILINE
  • 14611-51-9
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