N,N-dimethylarginine
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- CAS-Nr.
- 30315-93-6
- Englisch Name:
- N,N-dimethylarginine
- Synonyma:
- ArginineImpurity12;H-Arg(NMe2)-OH(asym);N,N-dimethylarginine;Asymmetric dimethylarginine;Asymmetric dimethylarginine(ADMA);L-Arg(Me,Me)-OH(asymmetrical), >97%;N(omega),N(omega)-dimethyl-L-arginine;L-Ornithine, N5-[(dimethylamino)iminomethyl]-;Arginine Impurity 12（N, N-Dimethyl-L-Arginine）;N5-[(Dimethylamino)iminomethyl]-L-ornithine, 97%
- CBNumber:
- CB21351907
- Summenformel:
- C8H18N4O2
- Molgewicht:
- 202.25
- MOL-Datei:
- 30315-93-6.mol
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N,N-dimethylarginine Eigenschaften
- Siedepunkt:
- 340.8±52.0 °C(Predicted)
- Dichte
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- L?slichkeit
- DMF: 5 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): freely soluble
- Aggregatzustand
- A crystalline solid
- pka
- 2.50±0.24(Predicted)
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
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N,N-dimethylarginine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Metabolomics
Definition
ChEBI: A L-arginine derivative having two methyl groups both attached to the primary amino moiety of the guanidino group.
Allgemeine Beschreibung
Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Asymmetric dimethylarginine is created in protein methylation, a common mechanism of post-translational protein modification. This reaction is catalyzed by an enzyme set called S-adenosylmethionine protein N-methyltransferases (protein methylases I and II). The methyl groups transferred to create ADMA are derived from the methyl group donor S-adenosylmethionine, an intermediate in the metabolism of homocysteine. (Homocysteine is an important blood chemical, because it is also a marker of cardiovascular disease). After synthesis, ADMA migrates into the extracellular space and then into blood plasma.
N,N-dimethylarginine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N,N-dimethylarginine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 54)Lieferanten
30315-93-6()Verwandte Suche:
- N,N-dimethylarginine
- (S)-2-Amino-5-(3,3-dimethylguanidino)pentanoic acid
- N(omega),N(omega)-dimethyl-L-arginine
- N5-[(Dimethylamino)iminomethyl]-L-ornithine, 97%
- N,N-dimethylarginine, 2-amino-5-(3,3-dimethylguanidino)pentanoic acid L-Arg(Me, Me)-OH (asymmetrical)
- Asymmetric dimethylarginine
- Arginine Impurity 12（N, N-Dimethyl-L-Arginine）
- L-Arg(Me,Me)-OH(asymmetrical), >97%
- L-Ornithine, N5-[(dimethylamino)iminomethyl]-
- ArginineImpurity12
- H-Arg(NMe2)-OH(asym)
- Inhibitor,Endogenous Metabolite,NOS,NO Synthase,Asymmetric dimethylarginine,inhibit,Nitric oxide synthases
- Asymmetric dimethylarginine(ADMA)
- 30315-93-6
