KP 103 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

In October 2013, efinaconazole (also known as KP-103) was approved in Canada as a 10% topical solution for the treatment of onychomycosis. Like other azole antifungal agents, efinaconazole acts by disrupting fungal cell membranes through inhibition of sterol 14α-demethylase, an enzyme involved in the biosynthesis of ergosterol, which is a key component of the fungal cell membrane. Efinaconazole has potent antifungal activity against clinical isolates of dermatophytes, including Trichophyton mentagrophyes (MIC₈₀ =0.125 μg/mL) and Trichophyton rubrum (MIC₈₀ =0.25 μg/mL), as well as against Candida and Malassezia species. Unlike other antifungal agents, efinaconazole retains activity in the presence of keratin, indicating that more unbound drug is available at the site of action. Efinaconazole is efficacious in guinea-pig models of fungal infection. Efinaconazole is prepared by reaction of an epoxide intermediate with 4-methylenepiperidine.

Verwenden

Efinaconazole has been used as:

• a topical anti-onychomycosis drug to determine its effects on Trichophyton rubrum and Trichophyton interdigitale
• as an anti-fungal agent to study its permeability into the nail lysates
• as an anti-fungal agent to study its effects on Candida africana and Candida dubliniensis

Definition

ChEBI: A member of the class of triazoles that is butan-2-ol which is substituted at positions 1, 2, and 3 by 1,2,4-triazol-1-yl, 2,4-difluorophenyl, and 4-methylenepiperidin-1-yl groups, respectively (the 2R,3R stereoisomer). It is an antifungal drug used for the topical treatment of onychomycosis (a nail infection caused mainly by dermatophytes).

KP 103 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

KP 103 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Jinan Qinmu Fine Chemical Co.,Ltd.	+8618660799346	sales@qinmuchem.com	China	1009	58
Guangzhou TongYi biochemistry technology Co.,LTD	+8613073028829	mack@tongyon.com	China	2994	58
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +8615064153060	sales01@jndxj.com	China	291	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	988	58
Firsky International Trade (Wuhan) Co., Ltd	+8615387054039	admin@firsky-cn.com	China	427	58
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	sales@anbuchem.com	China	2998	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10986	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Cangzhou Kangrui Pharma Tech Co. Ltd.,	+86-18632776803 +86-13833998158	cangzhoukangrui@126.com	China	733	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60

164650-44-6()Verwandte Suche:

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• KP 103
• KP 103 (pharmaceutical)
• (2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol
• Efinaconazole(KP 103)
• (R,R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol
• (αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol
• 1-Piperidineethanol, α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR)-
• Efinaconazole (Jublia)
• KP 103 USP/EP/BP
• EfinaconazoleQ: What is Efinaconazole Q: What is the CAS Number of Efinaconazole Q: What is the storage condition of Efinaconazole Q: What are the applications of Efinaconazole
• Efinaconazole 13CD2
• Efinaconazole 13CD6
• Efinaconazole D4Q: What is Efinaconazole D4 Q: What is the CAS Number of Efinaconazole D4
• Efinaconazole
• (alphaR,betaR)-alpha-(2,4-Difluorophenyl)-beta-methyl-4-methylene-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol
• Jublia
• JUBLIA; KP 103; KP103
• Efinaconzole
• Efluconazole
• (2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (Efinaconazole)
• Efinaconazole In-House
• 164650-44-6
• 1644650-44-6
• 164650-44-7
• C18H22F2N4O
• Inhibitors
• API