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PARECOXIB SODIUM

PARECOXIB SODIUM Struktur
198470-85-8
CAS-Nr.
198470-85-8
Englisch Name:
PARECOXIB SODIUM
Synonyma:
Dynastat;Rayzon;SC 69124A;Parecoxib CRS;parexib sodium;Parecoxib-011-Na;Parecoxib sodium;Parecoxib sodiuM sal;Parecoxib sodiuM salt;Parecoxib Impurity 64
CBNumber:
CB21003464
Summenformel:
C19H19N2NaO4S
Molgewicht:
394.42
MOL-Datei:
198470-85-8.mol

PARECOXIB SODIUM Eigenschaften

Schmelzpunkt:
273-275°C
storage temp. 
Inert atmosphere,2-8°C
L?slichkeit
DMF: 10mg/mL; DMSO: 15mg/mL; Ethanol: 3mg/mL; PBS (pH 7.2): 5mg/mL
Aggregatzustand
Powder
Farbe
White to off-white
InChI
InChI=1S/C19H18N2O4S.Na.H/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;;/h4-12H,3H2,1-2H3,(H,21,22);;
InChIKey
OGSQVUBPCQXSGW-UHFFFAOYSA-N
SMILES
CC1ON=C(C2C=CC=CC=2)C=1C1C=CC(S(=O)(=O)NC(=O)CC)=CC=1.[NaH]
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung GHS hazard pictogramssrc="/GHS02.jpg" width="20" height="20" /> P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

PARECOXIB SODIUM Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib . It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC50 value of 2.4 μM in HEK293 cells. It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg).

Chemische Eigenschaften

White Solid

Verwenden

Anti-inflammatory, analgesic.

Application

Parecoxib sodium is a water-soluble sodium salt of the amide prodrug of valdecoxib. Parecoxibundergoes enzymatic hydrolysis in vivo to the active moiety valdecoxib, and is formulated as apowder for solution for parenteral administration. Valdecoxib is a selective inhibitor of the enzymeCOX-2.

Biologische Funktion

A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.

PARECOXIB SODIUM Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PARECOXIB SODIUM Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 394)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu Aslee Biopharmaceuticals, Inc.
28-85305008
CHINA 964 58
Jiangsu Yutian pharmaceutical Co.,Ltd.
+undefined-0518-86098006 +undefined19851887368
 lvan.hui@jsytsw.com China 80 58
Hangzhou Benoy Chemical Co., Ltd
+8617342059697
 sales@benoychem.com China 315 58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD
+86-576-88902229;+86-0576-88902229 +8613968687450
 yuxin@yuxchem.com China 167 58
Shandong Hanjiang Chemical Co., Ltd
+86-0533-2066820 +8618369939125
 hanson@sdhanjiang.com China 999 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578
 sales@hbmojin.com China 12835 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971
 deasea125996@gmail.com China 2472 58
Sigma Audley 		+86-15937194204 +86-18126314766
 nova@sh-teruiop.com China 493 58
airuikechemical co., ltd. 		+undefined86-15315557071
 sales02@sdzhonghuimaterial.com China 983 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 +86-18600796368
 sales@sjar-tech.com China 395 58

198470-85-8()Verwandte Suche:

  • N-[4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)PHENYLSULFONYL]PROPIONAMIDE, SODIUM SALT
  • Parecoxib sodiuM salt
  • N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanaMide SodiuM Salt
  • Rayzon
  • SC 69124A
  • PropanaMide,N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodiuM salt (1:1)
  • Parecoxib sodiuM cloth
  • Parecoxib sodium N-[4-(5-Methyl-3-phenylisoxazol-4-yl)phenylsulfonyl]propionamide sodium salt
  • Parecoxib Sodium Impurity
  • Parecoxib sodiuM sal
  • Parecoxib sodium （Intermediate in China ONLY）
  • sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide
  • Parecoxib-011-Na
  • Parecoxib Impurity 64
  • PARECOXIB SODIUM USP/EP/BP
  • sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonysodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl) (propionyl)amidel) (propionyl)amide
  • N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide Sodium Salt（Parecoxib Sodium）
  • Dynastat
  • N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonyl]propanamide sodium hydride
  • Parecoxib sodium
  • Parecoxib Impurity 22 Sodium Salt
  • Parecoxib CRS
  • parexib sodium
  • Parecoxib Impurity 11 Sodium Salt
  • 198470-85-8
  • 98470-85-8
  • 198470-85-5
  • 10.98470-85-8
  • C19H17N2NaO4S
  • C19H17N2O4SNa
  • C19H18N2O4SNa
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 198470-85-8
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