ANTI-PHOSPHO-TRKA (PHOSPHOTYROSINE 490) Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-phospho-TrkA (pTyr
490) antibody can be used in immunoprecipitation, immunoblotting and immunohistochemistry. It may also be used in western blotting when diluted to ratio of 1:1000 for NGF-treated PC12 cells.
Allgemeine Beschreibung
TrkA belongs to the Trk proto-oncogene family and is expressed mainly in central and peripheral nervous systems. When TrkA binds to NGF, it autophosphorylates tyrosine residues like-Tyr
490, Tyr
674, Tyr
675, Tyr
751, and Tyr
785 and subsequently activates many downstream effector proteins. Defects in TrkA lead to congenital insensitivity to pain with anhidrosis. Anti-phospho-TrkA (pTyr
490) antibody can be used in immunocytochemistry (1:100, using cultured cells). It is also useful in identifying endogenous levels of phosphorylated Tyr
490 in TrkA, TrkB and TrkC. Rabbit anti- phospho-TrkA (pTyr
490) antibody is reactive in mouse, human and rat.
ANTI-PHOSPHO-TRKA (PHOSPHOTYROSINE 490) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte