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Mc-Val-Ala-PAB-PNP

Mc-Val-Ala-PAB-PNP Struktur
1639939-40-4
CAS-Nr.
1639939-40-4
Englisch Name:
Mc-Val-Ala-PAB-PNP
Synonyma:
Mc-Val-Ala-PAB-PNP;inhibit,ADC Linkers,Inhibitor,MC Val Ala PAB PNP,Antibody-drug conjugates linkers,MCValAlaPABPNP;L-Alaninamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-;4-((S)-2-((S)-2-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)propanamido)benzyl (4-nitrophenyl) carbonate
CBNumber:
CB15479729
Summenformel:
C32H37N5O10
Molgewicht:
651.66
MOL-Datei:
1639939-40-4.mol

Mc-Val-Ala-PAB-PNP Eigenschaften

Siedepunkt:
946.4±65.0 °C(Predicted)
Dichte
1.323±0.06 g/cm3(Predicted)
pka
13.31±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white
InChIKey
VMOQJVBAOUFRSX-LGGPFLRQSA-N
SMILES
C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1

Sicherheit

Mc-Val-Ala-PAB-PNP Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Mc-Val-Ala-PAB-PNP is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). Cryptophycin-55 (CR55) can be conjugated to the model antibody trastuzumab (an anti-HER2 antibody drug approved by the FDA for the treatment of breast cancer) through the linker of Mc-NHS and Mc-Val-Cit-PAB-PNP to prepare trastuzumab-CR55 conjugates. These conjugates exhibit potent cytotoxicity in HER2-positive tumor cell lines, with IC50 values at low nanomolar levels (0.58-1.19 nM)[1].

Mc-Val-Ala-PAB-PNP Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Mc-Val-Ala-PAB-PNP Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • Mc-Val-Ala-PAB-PNP
  • L-Alaninamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
  • 4-((S)-2-((S)-2-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)propanamido)benzyl (4-nitrophenyl) carbonate
  • inhibit,ADC Linkers,Inhibitor,MC Val Ala PAB PNP,Antibody-drug conjugates linkers,MCValAlaPABPNP
  • 1639939-40-4
  • Linker
  • ADC LINKER
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