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PROTEIN C

PROTEIN C Struktur
42617-41-4
CAS-Nr.
42617-41-4
Englisch Name:
PROTEIN C
Synonyma:
APC;DP2.5;PROTEIN C;APC, HUMAN;APC protein;HUMAN PROTEIN C;fromhumanplasma;PROTEIN C, HUMAN;activated protein c;PROTEIN C, ACTIVATED
CBNumber:
CB1469635
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

PROTEIN C Eigenschaften

storage temp. 
-20°C
L?slichkeit
H2O: 1 mg/mL
Aggregatzustand
lyophilized powder

Sicherheit

Kennzeichnung gef?hrlicher B
R-S?tze: 36/37
S-S?tze: 36/37-36-26
WGK Germany  3

PROTEIN C Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37:Reizt die Augen und die Atmungsorgane.

S-S?tze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Drotrecogin alfa was introduced in the US as a new intravenous treatment for the reduction of mortality in adult patients with severe sepsis associated with acute organ dysfunction. Drotrecogin aifa is the first recombinant activated protein C expressed in human kidney 293 cells. Activated protein C1 an endogenous serine protease, acts as an antithrombotic via inhibition of factor Va and Vllla, promotes fibrinolysis via inactivation of plasminogen-activator inhibitor-1 and exerts an anti-inflammatory effect by inhibiting the production of inflammatory cytokines (tumor necrosis factor-alpha, interieukin-1 and 6) by monocytes. It was shown that the majority of patients with sepsis have reduced levels of activated protein C. In a baboon model of lethal E. coli sepsis, administration of activated protein C reduced mortality. In a phase III clinical trial, intravenous infusion of drotrecogin alfa at a dose of 24 μg/kg/h over 96 h significantly reduced the risk of death compared with placebo in patients with severe sepsis. However, an increased risk of serious bleeding has been associated with the administration of the drug.

Verwenden

Protein C from human plasma has been used for pre-treatment of endothelial cells prior to antibody-inhibition assay. It has also been used in activated protein C (APC) assay to determine its inhibitory effect on copper.

Allgemeine Beschreibung

Protein C from human plasma is encoded by the gene PROC. In human chromosome, the gene is localised on chromosome 2q14. Activated protein C (APC) cleaves protease activated receptor 1 (PAR1) resulting in cytoprotective and anti-inflammatory effects. Clinical trials with APC implicates its use in treating severe early onset preeclampsia in pregnant women and prolongs pregnancy and helps in perinatal outcomes.

PROTEIN C Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


PROTEIN C Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 22)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Creative Enzymes
1-516-855-7709
info@creative-enzymes.com United States 8748 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
3bsc@sina.com China 15839 69
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80
Guangzhou Tomums Life Science Co., Ltd. 020-31155029 18902330969
sales@tomums.cn China 4696 58
Energy Chemical 021-58432009 400-005-6266
marketing@energy-chemical.com China 44918 58
Shanghai Huzhen Industrial Co., LTD 021-60345367 13916550749
sales@shzbio.com China 9966 58

42617-41-4()Verwandte Suche:


  • PROTEIN C, ACTIVATED, HUMAN
  • PROTEIN C
  • PROTEIN C, ACTIVATED
  • PROTEIN C, HUMAN PLASMA
  • PROTEIN C CONTROL PLASMA
  • PROTEIN C, HUMAN
  • PROTEIN C, ACTIVATED, HUMAN PLASMA
  • HUMAN PROTEIN C
  • APC
  • APC, HUMAN
  • adenomatous polyposis of the colon gene
  • Anti-APC, C-Terminal antibody produced in rabbit
  • APC protein
  • DP2.5
  • ACTIVATED HUMAN PROTEIN C
  • PROTEIN C, ACTIVATED FROM HUMAN PLASMA
  • fromhumanplasma
  • activated protein c
  • protein c from human plasma
  • protein C, des-1-41 light chain activated-
  • BLOOD-COAGULATION FACTOR XIVA
  • Protein C from human plasma Activated, lyophilized powder, >=90% (SDS-PAGE)
  • Native Human Protein C
  • 42617-41-4
  • Biochemicals and Reagents
  • BioChemical
  • Proteolytic Enzymes
  • Proteolytic Enzymes and Substrates
  • Enzymes, Inhibitors, and Substrates
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