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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Struktur
6318-41-8
CAS-Nr.
6318-41-8
Englisch Name:
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
Synonyma:
AS-041164, PI3K gamma inhibitor;PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem;2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-;5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione;Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K
CBNumber:
CB13232856
Summenformel:
C11H7NO4S
Molgewicht:
249.24
MOL-Datei:
6318-41-8.mol

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Eigenschaften

Dichte
1.595±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
L?slichkeit
Soluble in DMSO (up to 25 mg/ml).
Aggregatzustand
Yellow solid
pka
7.13±0.20(Predicted)
Farbe
Yellow
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM), compared to PI3Kα (IC50 = 240 nM), PI3Kβ (IC50 = 1.45 μM), and PI3Kδ (IC50 =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 24)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 5926 55
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11218 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
 order@med-bio.cn China 8140 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223;
 psaitong@jm-bio.com China 29774 58
Bide Pharmatech Ltd. 400-1647117 13681763483
 product02@bidepharm.com China 62075 58
InvivoChem 13549236410
 sales@invivochem.cn China 6753 58
TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24644 58

6318-41-8()Verwandte Suche:

  • 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
  • PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem
  • Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K
  • 5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione
  • AS-041164, PI3K gamma inhibitor
  • 6318-41-8
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