bpV(phen) (potassium hydrate) Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC
50 = 38 nM). It also inhibits the vascular endothelial PTP, PTP-
β (IC
50 = 343 nM), and PTP-
1β (IC
50 = 920 nM). At 0.1 mM, bpV(phen) inhibits SH2 domain-
containing inositol 5’-
phosphatase-
2. Presumably by inhibiting insulin receptor kinase-
associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-
kinase.
bpV(phen) (potassium hydrate) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte