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3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Struktur
913830-15-6
CAS-Nr.
913830-15-6
Englisch Name:
3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
Synonyma:
NS 9283;NS-9283;NS9283;NS 9283;NS-9283;NS9283;3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile;3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile;Benzonitrile, 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]-;NS9283,Inhibitor,Nicotinic acetylcholine receptors,nAChR,inhibit
CBNumber:
CB13049683
Summenformel:
C14H8N4O
Molgewicht:
248.24
MOL-Datei:
913830-15-6.mol

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Eigenschaften

Siedepunkt:
469.9±55.0 °C(Predicted)
Dichte
1.37±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 3 mg/ml; Ethanol: Partially soluble
Aggregatzustand
A crystalline solid
pka
1.40±0.12(Predicted)
Farbe
White to off-white

Sicherheit

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

NS 9283 is a positive allosteric modulator of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs) that potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs (EC50 = 4 μM). In vivo, NS 9283 potentiates ABT-594 analgesic efficacy in rat models of carrageenan-induced thermal hyperalgesia, paw skin incision post-operative pain, and monoiodoacetate-induced osteoarthritis. It reduces nicotine, but not sucrose, self-administration and reinstatement in rats when administered at a dose of 3.5 mg/kg.

Verwenden

NS 9283 is a positive allosteric modulator of α4β2 receptor affecting the potency of acetylcholine (Ach) related events. This has been linked to affect on everyday brain function including cognitive function and pain alleviation.

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 38)Lieferanten
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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  • 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
  • NS 9283
  • 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
  • NS 9283;NS-9283;NS9283
  • NS-9283;NS9283
  • Benzonitrile, 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]-
  • NS9283,Inhibitor,Nicotinic acetylcholine receptors,nAChR,inhibit
  • 913830-15-6
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