2-(4-Fluorophenyl)-thiophene
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- CAS-Nr.
- 58861-48-6
- Englisch Name:
- 2-(4-Fluorophenyl)-thiophene
- Synonyma:
- 2-(4-FL;AKOS BAR-1344;Canagliflozin INT2;IFLAB-BB F2108-0130;Impurity of caglitazin;FLUOROPHENYL)THIOPHENE;Cagliflozin Impurity 14;2-(4-Fluorphenyl)thiophen;Capagliflozin impurity 57;2-(4-fluorophenyl)thiophen
- CBNumber:
- CB1294813
- Summenformel:
- C10H7FS
- Molgewicht:
- 178.23
- MOL-Datei:
- 58861-48-6.mol
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2-(4-Fluorophenyl)-thiophene Eigenschaften
- Schmelzpunkt:
- 51.0 to 55.0 °C
- Siedepunkt:
- 252.3±15.0 °C(Predicted)
- Dichte
- 1.200±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- L?slichkeit
- soluble in Methanol
- Aggregatzustand
- powder to crystal
- Farbe
- Light orange to Yellow to Green
- InChI
- InChI=1S/C10H7FS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H
- InChIKey
- PURJRGMZIKXDMW-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=C(F)C=C2)SC=CC=1
- CAS Datenbank
- 58861-48-6
2-(4-Fluorophenyl)-thiophene Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
white solid
Verwenden
2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin (C175190) as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus.
Synthese
4-fluorobenzoic boric acid and 2-bromothiophene, Pd catalyst are added in organic solvent and dissolves, obtain material 3, wherein: 4-fluorine Phenylboric acid molar concentration in organic solvent is 0.5mol/L～2mol/L, and 4-fluorobenzoic boric acid with the mol ratio of 2-bromothiophene is 1:1.0～1:1.5,4-fluorobenzoic boric acid is 1:0.005～1:0.1 with the mol ratio of catalyst；Using material 3 with as material 4 Inorganic base aqueous solution carries out pre-incubation respectively to being 1:1.0～1 according to the mol ratio of 4-fluorobenzoic boric acid Yu alkali after reaction temperature: The mode of 3.0 mixes, and reacts under conditions of 50 ℃～80 ℃, then carries out post processing and obtains 2-(4-fluorophenyl) Thiophene.
2-(4-Fluorophenyl)-thiophene Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-(4-Fluorophenyl)-thiophene Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 369)Lieferanten
- IFLAB-BB F2108-0130
- 2-(4-FLUOROPHENYL)THIOPHENE
- AKOS BAR-1344
- Thiophene, 2-(4-fluorophenyl)-
- Canagliflozin Intermediate I
- Canagliflozin INT2
- 2-(4-fluorophenyl)thiophen
- Canagliflozin Related Impurity 14
- Cagliflozin Impurity 14
- 2-(4-Fluorophenyl)thiophene>
- 2-(4-FL
- Impurity of caglitazin
- 2-(4-FLUOROPHENYL)THIOPHENE 58861-48-6
- 2-(4-FLUOROPHENYL)THIOPHENE ISO 9001：2015 REACH
- Canagliflozin intermediate
- 2-(4-Fluorphenyl)thiophen
- 2-(p-Fluorophenyl)thiophene
- FLUOROPHENYL)THIOPHENE
- Capagliflozin impurity 57
- 58861-48-6
- 58861-48-6
