LL Z1640-2
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- CAS-Nr.
- 253863-19-3
- Englisch Name:
- LL Z1640-2
- Synonyma:
- nol;C 292;L 783279;FR148083;f 152 A1;5Z-7-Oxoze&ÆTAK1 inhibitor 5ZO);5Z-7-Oxozeaenol >=98% (HPLC);1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-;(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
- CBNumber:
- CB12744545
- Summenformel:
- C19H22O7
- Molgewicht:
- 362.37
- MOL-Datei:
- 253863-19-3.mol
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LL Z1640-2 Eigenschaften
- Schmelzpunkt:
- 171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
- Siedepunkt:
- 666.8±55.0 °C(Predicted)
- Dichte
- 1.270±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: >10mg/mL
- Aggregatzustand
- powder
- pka
- 7.32±0.70(Predicted)
- Farbe
- white to off-white
LL Z1640-2 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.
Biochem/physiol Actions
The anti-inflammatory effects of 5Z-7-oxozeaenol may affect cardiac hypertrophy.
LL Z1640-2 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
LL Z1640-2 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 34)Lieferanten
- f 152 A1
- C 292
- FR148083
- L 783279
- (2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
- TAK1 inhibitor 5ZO)
- 1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-
- 5Z-7-Oxozeaenol >=98% (HPLC)
- nol
- 5Z-7-Oxoze&Æ
- 253863-19-3
