1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate (aMMoniuM salt) Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Glycerophospholipids act as regulators of various enzyme activities, and can be used as biological markers to indicate pathological states.
Allgemeine Beschreibung
Lysophosphatidic?acid (LPA) is a class of phospholipids, which is water-soluble. It has a glycerol backbone attached?via?a phosphate group, an aliphatic chain and a hydroxyl group.?The aliphatic chain is linked to either?
sn-1 or?
sn-2 position and the phosphate group is connected to the?
sn-3 position. The hydroxyl group is linked to the remaining?
sn-1 or?
sn-2?position.
Biochem/physiol Actions
Lysophosphatidic?acid (LPA) is a signaling molecule and alters various cellular responses through G protein-coupled receptors (GPCRs). It stimulates smooth muscle contraction, cytoskeleton rearrangement and chemotaxis. LPA is also involved in inducing neurotransmitter release, cell proliferation, platelet aggregation and Ca2+ mobilization. Increased levels of LPA in human plasma leads to ovarian cancer and atherosclerosis. LPA acts as a potential biomarker for ovarian cancer.
1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate (aMMoniuM salt) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
