(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine
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- CAS-Nr.
- 327623-37-0
- Englisch Name:
- (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine
- Synonyma:
- Aprepitant Impurity 1;Aprepitant Impurity 11;Fosaprepitant Impurity 30;Aprepitant M2 Metabolite Enantiomer;Aprepitant Impurity 1 Hydrochloride;Aprepitant Impurity 10 Hydrochloride;Aprepitant M2 Metabolite (1S, 2S, 3R)-Isomer;Des-1,2,4-triazol-3-one-5-methyl(2S,3R,1’Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'S)-Aprepitant;(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine
- CBNumber:
- CB12657010
- Summenformel:
- C20H18F7NO2
- Molgewicht:
- 437.35
- MOL-Datei:
- 327623-37-0.mol
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(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Eigenschaften
- Siedepunkt:
- 387.9±42.0 °C(Predicted)
- Dichte
- 1.37±0.1 g/cm3(Predicted)
- pka
- 6.93±0.60(Predicted)
Sicherheit
(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1''S)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 40)Lieferanten
- (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine
- (2S,3R)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride
- (2S,3R)-2-[(1S)-1-(3,5-bis-trifluoro-Methylphenyl)ethoxy]-3-(4-fluorophenyl)Morpholine
- Aprepitant Impurity 1
- Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'S)-Aprepitant
- Aprepitant Impurity 11
- Aprepitant M2 Metabolite (1S, 2S, 3R)-Isomer
- Fosaprepitant Impurity 30
- Aprepitant Impurity 1 Hydrochloride
- Aprepitant M2 Metabolite Enantiomer
- Morpholine, 2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)-
- Des-1,2,4-triazol-3-one-5-methyl(2S,3R,1&rsquo
- Aprepitant Impurity 10 Hydrochloride
- 327623-37-0
