1,4-dihydronicotinaMide riboside
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- CAS-Nr.
- 19132-12-8
- Englisch Name:
- 1,4-dihydronicotinaMide riboside
- Synonyma:
- Anti-aging;1,4-Dihydronicotimideriboside;Reduced nicotinamide riboside;1,4-dihydronicotinaMide riboside;Reduced nicotinamide riboside(NRH);1-(β-D-Ribofuranosyl)-1,4-dihydronicotinamide;1,4-Dihydro-1-β-D-ribofuranosyl-3-pyridinecarboxamide;D-Ribofuranosyldihydronicotinamide, mixture of isomers;3-Pyridinecarboxamide, 1,4-dihydro-1-β-D-ribofuranosyl-;1-(D-Ribo furanosyl)-1,4-dihydro-3-pyridine carboxamide
- CBNumber:
- CB12648605
- Summenformel:
- C11H16N2O5
- Molgewicht:
- 256.26
- MOL-Datei:
- 19132-12-8.mol
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1,4-dihydronicotinaMide riboside Eigenschaften
- Siedepunkt:
- 598.3±50.0 °C(Predicted)
- Dichte
- 1.539±0.06 g/cm3(Predicted)
- pka
- 13.37±0.70(Predicted)
- InChI
- InChI=1/C6H8N2O.C5H10O5/c7-6(9)5-2-1-3-8-4-5;6-2-1-10-5(9)4(8)3(2)7/h1,3-4,8H,2H2,(H2,7,9);2-9H,1H2/t;2-,3-,4-,5?/s3
- InChIKey
- HMERANLWHIIDCI-UCPMJXAVNA-N
- SMILES
- C(N)(=O)C1=CNC=CC1.OC1OC[C@@H](O)[C@@H](O)[C@H]1O |&1:13,15,17,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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1,4-dihydronicotinaMide riboside Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Reduced Nicotinamide Riboside is a precursor which is an essential cofactor and substrate for many cells.
Biologische Aktivit?t
1,4-dihydronicotinamide riboside (NRH) is a potent NAD+ concentration enhancer both in vitro and in vivo. Researchers found that, after administration of NRH to mammalian cells, the NAD+ concentration increased by 2.5–10fold over control values in just one hour. Their findings demonstrate that the use of NRH is more effective than either NR or NMN. Moreover, NRH considerably enhances the NAD+/NADH ratio in the cultured cells without induction of apoptotic markers or a substantial increase in cell lactate levels. More recently, Canto et al. have found that contrary to the NR pathway, NRH uses different steps and enzymes to synthesize NAD+. That explains why NRH is a more effective and faster NAD+ precursor than NR in mammalian cells. In experiments with mice, the same researchers have also demonstrated that NRH is orally bioavailable as an NAD+ precursor and prevents cisplatin-induced acute kidney injury. In addition to increasing NAD+ levels, NRH can also deplete some genotoxins, such as hydrogen peroxide and methylmethane sulfonate. As a result, the mouse cells treated with NRH are resistant to cell death[1].
1,4-dihydronicotinaMide riboside Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1,4-dihydronicotinaMide riboside Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 22)Lieferanten
- 1,4-dihydronicotinaMide riboside
- 1-(D-Ribo furanosyl)-1,4-dihydro-3-pyridine carboxamide
- 3-Pyridinecarboxamide, 1,4-dihydro-1-β-D-ribofuranosyl-
- Reduced nicotinamide riboside
- D-Ribofuranosyldihydronicotinamide, mixture of isomers
- 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,4-dihydropyridine-3-carboxamide
- 1-(β-D-Ribofuranosyl)-1,4-dihydronicotinamide
- 1,4-Dihydro-1-β-D-ribofuranosyl-3-pyridinecarboxamide
- 1,4-Dihydronicotimideriboside
- Reduced nicotinamide riboside(NRH)
- Anti-aging
- 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
- 1,4-Dihydronicotinamide nucleoside (reduced nicotinamide ribose) NRH
- 19132-12-8
