2-Fluoro-4-nitrobenzoic acid
|
|
- CAS-Nr.
- 403-24-7
- Englisch Name:
- 2-Fluoro-4-nitrobenzoic acid
- Synonyma:
- NSC 190361;BUTTPARK 32\01-74;SALOR-INT L446572-1EA;Enzalutamide Impurity 25;2-Fluor-4-nitrobenzoic acid;2-Fluoro-4-nitrobenzotc acid;2-FLUORO-4-NITROBENZOIC ACID;2-chloro-4-nitrobenzoice acid;4-Carboxy-3-fluoronitrobenzene;Benzoicacid, 2-fluoro-4-nitro-
- CBNumber:
- CB1262658
- Summenformel:
- C7H4FNO4
- Molgewicht:
- 185.11
- MOL-Datei:
- 403-24-7.mol
|
2-Fluoro-4-nitrobenzoic acid Eigenschaften
- Schmelzpunkt:
- 170 °C
- Siedepunkt:
- 352.5±27.0 °C(Predicted)
- Dichte
- 1.568±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Aggregatzustand
- powder to crystal
- pka
- 2.37±0.13(Predicted)
- Farbe
- White to Light yellow
- BRN
- 2582091
- InChI
- InChI=1S/C7H4FNO4/c8-6-3-4(9(12)13)1-2-5(6)7(10)11/h1-3H,(H,10,11)
- InChIKey
- MMWFMFZFCKADEL-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C([N+]([O-])=O)C=C1F
- CAS Datenbank
- 403-24-7(CAS DataBase Reference)
2-Fluoro-4-nitrobenzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Chemische Eigenschaften
white to light yellow crystal powder
Synthese
A mixture of 2-fluoro4-nitrotoluene (31.1 g, 0.2 mol), tetrabutylammonium bromide (3.2 g,0.01 mol), 1.0 L of 1N NaOH, and KMnO4 (20.0 g) was stirred at room temperature. After 10 min, the resulting mixture was heated to 95 °Cwith stirring. Additional 30.0 g portions of KMnO 4 were added after 2 h and 3 h. After stirring at 95 °C for an additional 10 h, the reaction mixture was cooled to room temperature and filtered through Celite to remove MnO2. The filtrate was acidified to pH 2 by adding concentrated hydrochloric acid. An off-white precipitate formed that was collected by vacuum filtration. The crude solid was dissolved in 300 mL of 1N aqueous NaOH, acidified to pH 2 using concentrated hydrochloric acid, and the mixture extracted with CH 2 Cl 2 (3 × 200 mL). The combined CH2 Cl 2extracts were washed with 0.1 N aqueous HCl (2 × 100 mL), dried over anhydrous Na2SO4, and concentrated in vacuo to afford 27.3 g (73.7%)of 2-fluoro-4-nitrobenzoic acid as a white crystalline solid, m.p. 174.5–176.0 °C (lit 7. m.p. 176–177 °C)[1].
2-Fluoro-4-nitrobenzoic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Fluoro-4-nitrobenzoic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 417)Lieferanten
403-24-7()Verwandte Suche:
- 2-Fluoro-4-nitrobenzotc acid
- 0083512-Fluoro-4-nitrobenzoicacid
- 2-Fluoro-4-nitrobenzoic acid 98+%
- 4-Carboxy-3-fluoronitrobenzene
- 2-Fluor-4-nitrobenzoic acid
- NSC 190361
- 2-Fluoro-4-nitrobenzoic acid 97%
- Benzoicacid, 2-fluoro-4-nitro-
- 2-chloro-4-nitrobenzoice acid
- BUTTPARK 32\01-74
- SALOR-INT L446572-1EA
- 2-Fluoro-4-nitroBenzoicacid95+%
- 2-FLUORO-4-NITROBENZENECARBOXYLIC ACID
- 2-FLUORO-4-NITROBENZOIC ACID
- 2-Fluoride-4-Nitro Benzoic Acids
- 2-Fluoro-4-nitro2-Fluoro-4-nitrobenzoic acidbenzoic acid
- 2-Fluoro-4-nitrobenzoicAcid>
- Enzalutamide Impurity 25
- 3-2-Fluoro-4-nitrobenzoic acid
- 403-24-7
- 430-24-7
- C7H3FNO4
- Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
- intermediate
- Carboxylic Acids
- Phenyls & Phenyl-Het
- Benzoic acid
- Miscellaneous
- Carboxylic Acids
- Phenyls & Phenyl-Het