8(9)-EpETE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Eicosapentaenoic acid (EPA; ) is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE , relaxes vascular and airway smooth muscle by activating large conductance Ca
2+-
activated K
+ (BK
Ca) channels by directly interacting with BKα channel subunits. (±)8(9)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both
in vitro and
in vivo. The biological actions and physiological effects of this epoxide remain to be determined.
8(9)-EpETE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte