10-Hydroxycamptothecin
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- CAS-Nr.
- 64439-81-2
- Englisch Name:
- 10-Hydroxycamptothecin
- Synonyma:
- Irrotecan hCL;10-Hydroxycamptothec;10-ethylcaMptothecin;Hydroxy Camptothecine;10-Hydroxycamp-totecin;10-Hydroxycamptothecin;7ETHYHYDROXYCAMPTOTHECIN;(RS)-10-Hydroxycamptothecin;10-Hydroxyl-20(S)-Camptothecin;10-HYDROXYCAMPTOTHECIN ACETATE
- CBNumber:
- CB1233292
- Summenformel:
- C20H16N2O5
- Molgewicht:
- 364.35
- MOL-Datei:
- 64439-81-2.mol
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10-Hydroxycamptothecin Eigenschaften
- Schmelzpunkt:
- 230-237°C
- Siedepunkt:
- 820.7±65.0 °C(Predicted)
- Dichte
- 1.60
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMSO: ≥ 37.5 mg/mL (102.92 mM)
- Aggregatzustand
- Pale yellow powder
- pka
- 8.93±0.40(Predicted)
- Farbe
- Yellow
- InChI
- InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3
- InChIKey
- LCZZWLIDINBPRC-FQEVSTJZSA-N
- SMILES
- N1C2C(=CC(O)=CC=2)C=C2CN3C(C=12)=CC1C(CC)(O)C(=O)OCC=1C3=O
- CAS Datenbank
- 64439-81-2(CAS DataBase Reference)
10-Hydroxycamptothecin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
10-Hydroxycamptothecin: An Inhibitor of Topoisomerase I with Antitumor Activity
10-hydroxycamptothecin (10-HCPT) is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. 10-HCPT, a member of the camptothecin family, interferes with DNA synthesis by inhibiting the enzyme topoisomerase-I and has a broad spectrum of antitumor activity and less toxicity as camptothecins. However, 10-HCPT is insoluble in both water and physiological acceptable organic solvents and tends to change into its carboxylate form, which shows minimal antitumor activity and several unpredictable side effects. Therefore, appropriate drug delivery systems (DDS) for 10-HPCT have been developed to improve the stability of its lactone form. 10-HCPT is also an important precursor for the synthesis of clinically useful anticancer agents, such as irinotecan[1].
Chemische Eigenschaften
mp 268-270°C loss on drying <1%
Verwenden
Topoisomerase inhibitor
Einzelnachweise
[1] Chunjian Zhao. “Determination of Camptothecin and 10-Hydroxycamptothecin in Camptotheca acuminata by LC-ESI-MS/MS.” Analytical Letters 6 1 (2010): 2681–2693.
[2] Ruonan Shuang. “Pharmacokinetics of 10-hydroxycamptothecin–tetrandrine liposome complexes in rat by a simple and sensitive ultra-high performance liquid chromatography with tandem mass spectrometry.” Journal of separation science 43 3 (2019): 569–576.
10-Hydroxycamptothecin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
10-Hydroxycamptothecin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 274)Lieferanten
64439-81-2()Verwandte Suche:
- 10-HYDROXYCAMPTOTHECIN ACETATE
- 10-HYDROXYCAMPTOTHECIN ACETATE SALT
- 7-ETHYL-10-HYDROXY CAMPTHOTECIN
- Hydroxy Camptothecine
- 77-Ethyl-10-hydroxy campthotecin
- (20S)- 7-Ethyl-10-Hydroxycamptothecin
- 10-Hydroxycamp-totecin
- 7ETHYHYDROXYCAMPTOTHECIN
- 10-Hydroxyl-20(S)-Camptothecin
- (+/-)-4-Ethyl-4,9-dihydroxy-1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (20S)-4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
- 10-Hydroxycamptothecin
- 10-Hydroxycamptothec
- 10-ethylcaMptothecin
- 4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-3,14(4H,12H)-dione
- 10-Hydroxycamptothecin USP/EP/BP
- Irrotecan hCL
- Camptothecin, 10-Hydroxy-, Camptotheca acuminata - CAS 64439-81-2 - Calbiochem
- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,9-dihydroxy-
- 10-Hydroxycamptothecin, Hydroxycamptothecine ,HCPT, HPT
- Benzoicacid,3-(aminosulfonyl)-9-methyl-
- (RS)-10-Hydroxycamptothecin
- (Inverted exclamation markA)-10-Hydroxycamptothecin
- 4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 64439-81-2
- Inhibitors
- Antineoplastic
- Camptothecin series
