Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
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- CAS-Nr.
- 161798-01-2
- Englisch Name:
- Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
- Synonyma:
- ETHYL 2-(3-FORMYL-4-HYDROXYPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE;Febuxostat-23;Febuxostat
PI-2;-4-hydroxyphenyL;Febuxostat Impurity 1;Febuxostat Impurities1;Febuxostat Impurity Z17;Febuxostat intermediate3;Ethyl 2-(3-formyl-4-hydroxyphenyl);5-carboxylato-1-ethyl-2-(3-forMyl-4-h
- CBNumber:
- CB12128604
- Summenformel:
- C14H13NO4S
- Molgewicht:
- 291.32
- MOL-Datei:
- 161798-01-2.mol
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Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Eigenschaften
- Schmelzpunkt:
- 116 °C
- Siedepunkt:
- 446.7±55.0 °C(Predicted)
- Dichte
- 1.335
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 6.81±0.20(Predicted)
- Farbe
- Pale Yellow to Yellow
- InChI
- InChI=1S/C14H13NO4S/c1-3-19-14(18)12-8(2)15-13(20-12)9-4-5-11(17)10(6-9)7-16/h4-7,17H,3H2,1-2H3
- InChIKey
- NJRGQNNSIAFIJC-UHFFFAOYSA-N
- SMILES
- S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(O)C(C=O)=C1
- CAS Datenbank
- 161798-01-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P321 |
Besondere Behandlung |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate is a pharmaceutical intermediate used in the preparation of the xanthine oxidase inhibitor febuxostat, which is used in the treatment of hyperuricaemia and gout. It is also used in the synthesis of novel thiazolyl α-aminophosphonates.
Chemische Eigenschaften
Yellow or yellow powder
Verwenden
Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a product prepared via reaction 4-Hydroxybenzene-1-benzothiomide with ethyl-2-chloro acetoacetate. An antibacterial agent and antifungal activity against C.albicans.
Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 400)Lieferanten
| Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
|
HEBEI BRANT PHARMACEUTICAL CO.,LTD
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+86-311-84455288 +86-18832137600
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rice@brantpharm.com |
China |
17 |
58 |
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Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd
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+86-010-83386758 +86-18810831598
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jennifer@lianben.com |
China |
85 |
58 |
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Jinan Jianfeng Chemical Co., Ltd
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0531-88110457; +8615562555968
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info@pharmachemm.com |
China |
251 |
58 |
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Hebei Yanxi Chemical Co., Ltd.
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+8617531190177
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peter@yan-xi.com |
China |
5857 |
58 |
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Anhui Ruihan Technology Co., Ltd
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+8617756083858
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daisy@anhuiruihan.com |
China |
973 |
58 |
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Capot Chemical Co.,Ltd.
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+86-（0）57185586718 +86-13336195806
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sales@capot.com |
China |
29791 |
60 |
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Shanghai Daken Advanced Materials Co.,Ltd
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+86-371-66670886
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info@dakenam.com |
China |
18751 |
58 |
|
Beijing Cooperate Pharmaceutical Co.,Ltd
|
010-60279497
|
sales01@cooperate-pharm.com |
CHINA |
1803 |
55 |
|
Henan Tianfu Chemical Co.,Ltd.
|
+86-0371-55170693 +86-19937530512
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info@tianfuchem.com |
China |
21634 |
55 |
|
Hangzhou FandaChem Co.,Ltd.
|
+8615858145714
|
FandaChem@Gmail.com |
China |
9087 |
55 |
161798-01-2()Verwandte Suche:
- ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
- 2-(3-Formyl-4-hydroxy-phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester
- Thiazolecarboxylicacid,2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-,ethylester
- 5-carboxylato-1-ethyl-2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-1H-1$l^{4},3-thiazol-1-yl
- Ethyl 2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate
- 5-carboxylato-1-ethyl-2-(3-forMyl-4-h
- 5-Thiazolecarboxylicacid, 2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-, ethyl ester
- 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
- Febuxostat Impurity 1
- Febuxostat
PI-2
- Ethyl 2-(3-formyl-4-hydroxyphenyl)
- 2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylicacid ethyl ester
- Febuxostat-23
- Febuxostat intermediate3
- ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazo
- Febuxostat Impurity Z17
- ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-
- -4-hydroxyphenyL
- ethyl-2-(3-formyl-4-hydroxyphenyl)-4-methyl thiozole-5-carboxylate
- Febuxostat intermediates，Ethyl 2-(3-formyl-4-hydroxyphenyl)-4- methylthiazole-5-carboxylate
- Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate 2-
- Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carbox...
- Febuxostat Impurities1
- ETHYL 2-(3-FORMYL-4-HYDROXYPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
- Ethyl 2-(3- aldehyde -4- hydroxyphenyl) -4- methylthiazole -5- carboxylate
- Ethyl 2-(3-formyl-4-hydroxypheip)-4-methylthiazole-5-carboxylate
- 5-Thiazolecarboxylic acid, 2-(3-formyl-4-hydroxyphenyl)-4-methyl-, ethyl ester (9CI, ACI)
- 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-Thiazolecarboxylic acid ethyl ester (9CI ACI)
- 2-(3-formyl-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate
- Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate（F3）
- Ethyl 2-(3-formyl-4- hydroxyphenyl)-4-
- 2-(3-formyl-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylat
- 2- (3-aldehyde 4-hydroxyphenyl) -4-methylthiazole-5-carboxylic acid ethyl ester
- 161798-01-2
- Febuxostat intermediate
- 161798-01-2
