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L-THREO-DIHYDROSPHINGOSINE

L-THREO-DIHYDROSPHINGOSINE Struktur
15639-50-6
CAS-Nr.
15639-50-6
Englisch Name:
L-THREO-DIHYDROSPHINGOSINE
Synonyma:
SAFINGOL;L-threo-dihydrospingosine;L-THREO-DIHYDROSPHINGOSINE;L-THREO-SPHINGANINE, C18 CHAIN;L-threo-dihydrosphingosine (d18:0);L-threo-Dihydrosphingosine (Safingol);Safingol - CAS 15639-50-6 - Calbiochem;1,3-Octadecanediol, 2-amino-, (2S,3S)-;L-THREO-DIHYDROSPHINGOSINE (D18:0);SAFINGOL;L-threo-Dihydrosphingosine (Safingol), lyso-sphingolipid PKC inhibitor
CBNumber:
CB1192274
Summenformel:
C18H39NO2
Molgewicht:
301.51
MOL-Datei:
15639-50-6.mol

L-THREO-DIHYDROSPHINGOSINE Eigenschaften

Schmelzpunkt:
126-128 °C
Siedepunkt:
446.2±25.0 °C(Predicted)
Dichte
0.927±0.06 g/cm3(Predicted)
Flammpunkt:
110 °C
storage temp. 
-20°C
L?slichkeit
≤0.25mg/ml in ethanol
Aggregatzustand
White solid
pka
12.57±0.45(Predicted)

Sicherheit

WGK Germany  3

L-THREO-DIHYDROSPHINGOSINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

L-threo-Dihydrosphingosine is a lyso-sphingolipid protein kinase C inhibitor. It suppresses the growth of human oral squamous cell carcinoma (SCC) cells.

Allgemeine Beschreibung

A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Inhibits enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC (IC50 = 37.5 μM and 31 μM, respectively). Inhibits human PKCα, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 μM). Enhances the cytotoxic effect of the chemotherapeutic agent Mitomycin C (MMC; Cat. Nos. 47589 and 475820) in gastric cancer cells by promoting drug-induced apoptosis.

Biochem/physiol Actions

Sphingosine kinase inhibitor; protein kinase C alpha (PKCα) -specific inhibitor; Sphingosine analog; potentiates the effect of doxorubicin (DOX) in tumor-bearing animals.

L-THREO-DIHYDROSPHINGOSINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

L-THREO-DIHYDROSPHINGOSINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 67)Lieferanten
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  • SAFINGOL
  • L-THREO-SPHINGANINE, C18 CHAIN
  • L-THREO-DIHYDROSPHINGOSINE
  • L-threo-dihydrospingosine
  • L-THREO-DIHYDROSPHINGOSINE (D18:0);SAFINGOL
  • L-threo-dihydrosphingosine (d18:0)
  • 1,3-Octadecanediol, 2-amino-, (2S,3S)-
  • Safingol - CAS 15639-50-6 - Calbiochem
  • L-threo-Dihydrosphingosine (Safingol)
  • L-threo-Dihydrosphingosine (Safingol), lyso-sphingolipid PKC inhibitor
  • 15639-50-6
  • Biochemicals and Reagents
  • BioChemical
  • Lipids
  • Sphingolipids
  • Sphinganines
  • Sphingoid bases
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