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2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE

2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Struktur
194085-75-1
CAS-Nr.
194085-75-1
Englisch Name:
2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE
Synonyma:
YKP 509;RWJ 333369;Carisbamate;JNJ 10234094;(S)-Carisbamate;CarisbaMate (RWJ-333369);2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE;[(2S)-2-(2-chlorophenyl)-2-hydroxyethyl] carbamate;1,2-ETHANEDIOL,1-(2-CHLOROPHENYL)-, 2-CARBAMATE, (S)-;1,2-Ethanediol,1-(2-chlorophenyl)-, 2-carbaMate, (1S)-
CBNumber:
CB11474577
Summenformel:
C813CH8D2Cl15NO3
Molgewicht:
215.63
MOL-Datei:
194085-75-1.mol

2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Eigenschaften

Schmelzpunkt:
131-132°C
storage temp. 
Refrigerator
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
Farbe
White to Off-White

Sicherheit

2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Carisbamate is an antiepileptic agent., In vivo, administration of carisbamate (10-60 mg/kg) dose-dependently reduces spike and wave discharges in the frontoparietal cortex in a rat model of absence seizures. Carisbamate (10 mg/kg) increases latency to the first running episode in the Wistar audiogenic sensitive rat model of convulsive seizures. It also reduces motor seizure frequency in a rat model of spontaneous seizures in a dose-dependent manner. Carisbamate blocks Nav1.2 channels (IC50 = 68 μM for rat channels) and inhibits repetitive firing of action potentials in rat hippocampal neurons in a dose-dependent manner. It also reduces T-type Ca2+ currents in HEK cells transfected with human recombinant Cav3.1 channels at a concentration of 300 μM.

2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 29)Lieferanten
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  • 2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE
  • Carisbamate
  • (S)-Carisbamate
  • 1,2-Ethanediol,1-(2-chlorophenyl)-, 2-carbaMate, (1S)-
  • JNJ 10234094
  • RWJ 333369
  • YKP 509
  • CarisbaMate (RWJ-333369)
  • [(2S)-2-(2-chlorophenyl)-2-hydroxyethyl] carbamate
  • 1,2-ETHANEDIOL,1-(2-CHLOROPHENYL)-, 2-CARBAMATE, (S)-
  • 194085-75-1
  • C813CH8D2Cl15NO3
  • Amines
  • Aromatics
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Isotope Labelled Compounds
  • Pharmaceuticals
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