Sumatriptan succinate
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- CAS-Nr.
- 103628-48-4
- Englisch Name:
- Sumatriptan succinate
- Synonyma:
- SuMitrex;gr43175c;Sumatriptan succinat;Sumatriptan succinate;methanesulfonamide(1:1);SumatriptanSuccinate>Penehyclidine Impurity 9;SUMATRIPTANSUCCINATE(1:1);SuMatriptan Succinate, EP;Sumatriptan succinate CRS
- CBNumber:
- CB1135040
- Summenformel:
- C18H27N3O6S
- Molgewicht:
- 413.48848
- MOL-Datei:
- 103628-48-4.mol
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Sumatriptan succinate Eigenschaften
- Schmelzpunkt:
- 165-166°C
- storage temp.
- -20°C
- L?slichkeit
- H2O: >20mg/mL
- Aggregatzustand
- solid
- Farbe
- white to off-white
- Merck
- 14,8997
- BCS Class
- 3
- InChIKey
- PORMUFZNYQJOEI-UHFFFAOYSA-N
- CAS Datenbank
- 103628-48-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38-41 |
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| S-S?tze: |
26-36-39 |
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| RIDADR |
3077 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
EJ9940000 |
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| HS Code |
29350090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H412 |
Sch?dlich für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 3 |
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P273, P501 |
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| Sicherheit |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Sumatriptan succinate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Sumatriptan succinate is a highly selective 5HT
1-like receptor agonist introduced as a
new treatment for migraine. It is indicated for the acute relief of migraine and cluster
headache. Oral administration is reported to be free of substantial side effects. The
compound appears to be a significant advance over the use of ergotamine and other
agents in the treatment of migraine.
Chemische Eigenschaften
White Crystalline Powder
Verwenden
Sumatriptan Succinate is a selective 5-HT1B/1D-receptor agonist with anticonvulsant properties (1,2). Sumatriptan Succinate is used for migraine relief (2).
Definition
ChEBI: A succinate salt obtained by reaction of sumatriptan with one equivalent of succinic acid. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used for the acute treatm
nt of migraine with or without aura in adults.
Weltgesundheitsorganisation (WHO)
Suprofen, a nonsteroidal anti-inflammatory agent, was introduced
in 1983 for use as an analgesic for the symptomatic relief of mild to moderate pain
and for primary dysmenorrhoea. By 1986 it had become evident that its use was
occasionally associated with flank pain sometimes accompanied by evidence of
decreased renal function. The Arthritis Advisory Committee of the United States
Food and Drug Administration met in December 1986 to review the situation and
decided against withdrawing suprofen from the market. However, in May 1987 the
Committee for Proprietary Medicinal Products of the European Community
recommended that all marketing authorizations should be suspended. The
manufacturer subsequently decided to suspend sale worldwide on the grounds
that sales had diminished to the point where the product was no longer
economically viable.
Biologische Aktivit?t
Selective 5-HT 1 receptor agonist (K i values are 17, 27 and 100 nM at 5-HT 1D , 5-HT 1B and 5-HT 1A receptors respectively). Antimigraine agent.
Sumatriptan succinate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Sumatriptan succinate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 442)Lieferanten
103628-48-4()Verwandte Suche:
- 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide, Succinate, Imigran, Imitrex,
- Butanedioic acid, compd. with 3-2-(dimethylamino)ethyl-N-methyl-1H-indole-5-methanesulfonamide (1:1)
- SUMATRIPTANSUCCINATE(1:1)
- 1-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide succinate
- Sumatriptan succinate
- SuMatriptan Succinate, EP
- Sumatriptan Succinate (200 mg)
- SuMitrex
- 3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl-N-methylmethanesulfonamide Succinate
- (3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide succinic acid
- 3-[2-(DIMETHYLAMINO) ETHYL]-N-METHYL-1H-INDOLE-5-METHANE SULFONAMIDE
- compd.with3-(2-(dimethylamino)ethyl)-n-methyl-1h-indole-5-butanedioicaci
- gr43175c
- methanesulfonamide(1:1)
- 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide，butanedioate (1:1)
- SumatriptanSuccinateTablets
- Sumatriptan succinate, 98%, a 5-HT1 receptor agonist
- Sumatriptan succinate CRS
- Sumatriptan impurity mixture CRS
- SumatriptanSuccinate>
- Penehyclidine Impurity 9
- Sumatriptan succinate USP/EP/BP
- Sumatriptan succinat
- Sumatriptan Succinate (GR43175)
- Sumatriptan SuccinateQ: What is
Sumatriptan Succinate Q: What is the CAS Number of
Sumatriptan Succinate Q: What is the storage condition of
Sumatriptan Succinate Q: What are the applications of
Sumatriptan Succinate
- Sumatriptan Succinate (1642201)
- R = CH3: N-methyl(2-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-6-yl)methanesulfonamide
- [3-[2-(Dimethyl amino) ethyl]-1H-indol-5-yl]-N-methyl methane sulphonamide (Sumatriptan Base)
- Sumatriptan Succinate Impurity
- 103628-48-4
- C14H21N3O2SC4H6O4
- C13H19N3O2SC4H6O4
- C14H21N3O2SC4H6O6
- C14H21N3O2S
- Sumatriptan
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Indoles and derivatives
- OPTIMINE
- Serotonin receptor
