4-(1-Hydroxy-2-(methylamino)ethyl)phenol
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- CAS-Nr.
- 94-07-5
- Bezeichnung:
- 4-(1-Hydroxy-2-(methylamino)ethyl)phenol
- Englisch Name:
- Synephrine
- Synonyma:
- oxedrine;p-synephrine;4-(1-hydroxy-2-(methylamino)ethyl)phenol;SYNEPHERINE;1-[4-HYDROXYPHENYL]-2-METHYLAMINOETHANOL;s38537-9;simpalon;simpatol;synefrin;94-07-5-
- CBNumber:
- CB1129621
- Summenformel:
- C9H13NO2
- Molgewicht:
- 167.21
- MOL-Datei:
- 94-07-5.mol
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4-(1-Hydroxy-2-(methylamino)ethyl)phenol Eigenschaften
- Schmelzpunkt:
- 187 °C (dec.)(lit.)
- Siedepunkt:
- 295.79°C (rough estimate)
- Dichte
- 1.1222 (rough estimate)
- Brechungsindex
- 1.4680 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- Aggregatzustand
- Solid
- pka
- pKa 9.60±0.02(H2O
t = 25.0±0.5
I = 0.01)(Approximate)
- Farbe
- White to Off-White
- Merck
- 14,9012
- Stabilit?t:
- Hygroscopic
- InChI
- InChI=1/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3/t9-/s3
- InChIKey
- YRCWQPVGYLYSOX-DJEYLCQNNA-N
- SMILES
- C1(=CC=C(O)C=C1)[C@@H](O)CNC |&1:7,r|
- LogP
- -0.450
- CAS Datenbank
- 94-07-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
26-36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DO7350000 |
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| HS Code |
29225090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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4-(1-Hydroxy-2-(methylamino)ethyl)phenol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Synephrine, also known as Analeptin or p-synephrine, is naturally occurring alkaloid. It is an off-white to beige powder that is derived from the fruit of small citrus trees (Citrus aurantium). It is soluble in water, insoluble in ether, almost insoluble in chloroform, ether. Synephrine is related structurally to endogenous neurotransmitters (adrenaline and noradrenaline), and acts on several adrenergic and serotonergic receptors.
Verwenden
(±)-Synephrine has been used as an alkaloid to investigate its
in vitro antiviral, antibacterial, antifungal and cytotoxicity activities.
Application
Synephrine is a α-adrenergic receptor agonist, vasoconstrictor that has been reported to have thermogenic properties. Therefore, it is widely used as a dietary supplement to enhance energy and promote weight loss. It is reported that the (-)-form of synephrine has more potent than that of the (+)-form. (The product is for research purpose only.)
Definition
ChEBI: Synephrine is a phenethylamine alkaloid that is 4-(2-aminoethyl)phenol substituted by a hydroxy group at position 1 and a methyl group at the amino nitrogen. It has a role as a plant metabolite and an alpha-adrenergic agonist. It is a phenethylamine alkaloid, a member of phenols and a member of ethanolamines. It is a conjugate base of a synephrinium.
Allgemeine Beschreibung
Synephrine is a sympathomimetic amine from the plant?
Citrus aurantium and is identified as a major active component of dietary supplements.
4-(1-Hydroxy-2-(methylamino)ethyl)phenol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-(1-Hydroxy-2-(methylamino)ethyl)phenol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 474)Lieferanten
94-07-5(4-(1-Hydroxy-2-(methylamino)ethyl)phenol)Verwandte Suche:
- (+/-)-SYNEPHRINE
- SYNEPHRINE
- 4-hydroxy-alpha-(methylaminomethyl)benzyl alcohol
- AKOS NCG1-0008
- AURORA KA-6561
- DL-SYNEPHRINE
- 1-(4-hydroxyphenyl)-n-methylethanolamine
- 4-hydroxy-alpha-((methylamino)methyl)benzenemethanol
- alpha-(4-oxyphenyl)alpha-oxy-beta-methylaminoaethan
- analeptin
- p-Hydroxy-a-[(methylamino)methyl]benzyl alcohol
- 4-Hdroxy-alpha-(methylaminomethyl)benzyl alcohol
- (±)-Synephrine,1-(4-Hydroxyphenyl)-2-methylaminoethanol, 4-Hydroxy-α-(methylaminomethyl)benzyl alcohol
- 4-Hydroxy-α-(methylaminomethyl)benzyl alcohol
- rac-Synephrine
- Synephrine (Oxedrine)
- Oxedrine, BAN
- Synephrine SynonyMs 1-(4-Hydroxyphenyl)-2-(MethylaMino)ethanol
- Benzenemethanol, 4-hydroxy-α-[(methylamino)methyl]-
- Synephrine
1-(4-Hydroxyphenyl)-2-(methylamino)ethanol
- beta-methylamino-alpha-(4-hydroxyphenyl)ethylalcohol
- ethaphene
- methylaminomethyl(4-hydroxyphenyl)carbinol
- parakorper
- parasympatol
- pentedrin
- p-hydroxy-alpha-((methylamino)methyl)-benzylalcoho
- p-hydroxy-alpha-((methylamino)methyl)benzylalcohol
- p-hydroxyphenylmethylaminoethanol
- p-methylaminoethanolphenol
- p-oxedrine
- s38537-9
- simpalon
- simpatol
- sympathol
- synefrin
- synephrin
- synthenate
- 4-Hydroxy-α-[[methylamino] methyl] benzenemethanol
- p-Hydroxy-α-[[methylamino] methyl] benzyl alcohol
- Benzenemethanol, 4-hydroxy-.alpha.-(methylamino)methyl-
- SYNEPHRINE BASE
- PARA-SYNEPHRINE
- SYNEPHRINE 98+% HPLC FROM CITRUS AURANTIUM L.
- Synephrine (base and/or unspecified salts)
- Citrus aurantium P.E.95.0% Synephrine
- 4-Hydroxy-a-[(methylamino)methyl]benzenemethanol
- Sympathol ，Oxedrine
- 1-(4-Hydroxyphenyl)-2-methylaminoethanol, 4-Hydroxy-α-(methylaminomethyl)benzyl alcohol
- (+/-)-N-Methyloctopamine
- 4-Hydroxy-a-(methylaminomethyl)benzyl alcohol
- b-Methylamino-a-(4-hydroxyphenyl)ethyl alcohol
- Synephrine, 98%, from Citrus aurantium L.
- Benzenemethanol, 4-hydroxy-a-[(methylamino)menthyl]
- Synephrine CAS NO.94-07-5
- 4-[(1S)-1-hydroxy-2-(methylamino)ethyl]phenol
- Synephrine/Synephrine base
- Synephrine 95-98%
