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Dantrolen

Dantrolene Struktur
7261-97-4
CAS-Nr.
7261-97-4
Bezeichnung:
Dantrolen
Englisch Name:
Dantrolene
Synonyma:
C06939;DANTRILENE;Dantrolene (200 mg);Dantrolene (1163140);1-[5-(4-Nitrophenyl)-2-furylmethyleneamino]imidazolidine-2,4-dione;1-{(5-(4-NITROPHENYL)-2-FURANYL)METHYLENE}AMINO-2,4-IMIDAZOLIDENEDIONE;1-{[5-(4-nitrophenyl)-2-furyl]methylideneamino} imidazolidine-2,4-dione;1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione;1-(((5-(4-Nitrophenyl)furan-2-yl)methylene)amino)imidazolidine-2,4-dione;2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-
CBNumber:
CB0875659
Summenformel:
C14H10N4O5
Molgewicht:
314.25
MOL-Datei:
7261-97-4.mol

Dantrolen Eigenschaften

Schmelzpunkt:
279-280°
Siedepunkt:
453.94°C (rough estimate)
Dichte
1.3452 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
Store at -20°C
L?slichkeit
DMSO (Slightly), Methanol (Very Slightly, Sonicated)
Aggregatzustand
Solid
pka
7.68±0.10(Predicted)
Farbe
Yellow to Dark Yellow
Stabilit?t:
Hygroscopic
EPA chemische Informationen
Dantrolene (7261-97-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2934990002
Giftige Stoffe Daten 7261-97-4(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H336 Kann Schl?frigkeit und Benommenheit verursachen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Schl?frigkeit und Benommenheit) Warnung P261, P271, P304+P340, P312,P403+P233, P405, P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P403+P233 An einem gut belüfteten Ort aufbewahren. Beh?lter dicht verschlossen halten.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Dantrolen Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Dantrolene acts as a skeletal muscle relaxant through inhibition of Ca2+ release through ryanodine receptor channels.

Definition

ChEBI: The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin.

Allgemeine Beschreibung

Crystals (in aqueous DMF).

Air & Water Reaktionen

Slightly water soluble. Dantrolene may be sensitive to heat and air .

Reaktivit?t anzeigen

A nitrated amine derivative. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

SYMPTOMS: When ingested, symptoms of exposure may include drowsiness, dizziness, weakness, general malaise, fatigue, diarrhea, constipation, gastrointestinal bleeding, anorexia, abdominal cramps, hepatitis, speech disturbance, seizure, headache, light-headedness, insomnia, tachycardia, phlebitis, mental depression, mental confusion, nervousness, abdominal hair growth, rash, sweating, backache, chills and fever.

Brandgefahr

Flash point data for Dantrolene are not available. Dantrolene is probably combustible.

Dantrolen Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dantrolen Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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7261-97-4(Dantrolen)Verwandte Suche:


  • DANTRILENE
  • 1-{(5-(4-NITROPHENYL)-2-FURANYL)METHYLENE}AMINO-2,4-IMIDAZOLIDENEDIONE
  • 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione
  • 1-[5-(4-Nitrophenyl)-2-furylmethyleneamino]imidazolidine-2,4-dione
  • C06939
  • Dantrolene (200 mg)
  • HYDRATED 1-[[[5-(4-NITROPHENYL)-2-FURANYL]METHYLENE]AMINO]-2, 4-IMIDAZOLIDINEDIONE SODIUM SALT
  • 2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-
  • 1-{[5-(4-nitrophenyl)-2-furyl]methylideneamino} imidazolidine-2,4-dione
  • 1-(((5-(4-Nitrophenyl)furan-2-yl)methylene)amino)imidazolidine-2,4-dione
  • Dantrolene (1163140)
  • muscle spasticity,F368,inhibit,Inhibitor,neuroleptic malignant syndrome,F-368,Huntington's disease,Dantrolene,calcium signaling,malignant hyperthermia,F 368,ryanodine receptor,glutathione reductase
  • 7261-97-4
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