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N-(Aminoiminomethyl)-2,6-dichlorphenylacetamidmonohydrochlorid

GUANFACINE HCL Struktur
29110-48-3
CAS-Nr.
29110-48-3
Bezeichnung:
N-(Aminoiminomethyl)-2,6-dichlorphenylacetamidmonohydrochlorid
Englisch Name:
GUANFACINE HCL
Synonyma:
GUANFACINE HYDROCHLORIDE;Tenex;Intuniv;lon798;estulic;bs100-141;Guarfacine;Guanfascine;GUANFACINE HCL;Guanfacine HCL powder
CBNumber:
CB0767424
Summenformel:
C9H9Cl2N3O.ClH
Molgewicht:
282.55
MOL-Datei:
29110-48-3.mol

N-(Aminoiminomethyl)-2,6-dichlorphenylacetamidmonohydrochlorid Eigenschaften

Schmelzpunkt:
215-217℃
RTECS-Nr.
CY1481000
storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
H2O: 12 mg/mL at 60 °C, soluble
Aggregatzustand
Solid
Farbe
white
Merck 
14,4561
Stabilit?t:
Hygroscopic
InChIKey
DGFYECXYGUIODH-UHFFFAOYSA-N
CAS Datenbank
29110-48-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
RIDADR  3249
WGK Germany  3
HazardClass  6.1(b)
PackingGroup  III
HS Code  2925294500
Toxizit?t LD50 in mice: 165 mg/kg orally (Coward)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P321 Besondere Behandlung
P405 Unter Verschluss aufbewahren.

N-(Aminoiminomethyl)-2,6-dichlorphenylacetamidmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Centrally acting a-adrenoceptor agonist. Antihypertensive

Allgemeine Beschreibung

Guanfacine hydrochloride,N-(aminoiminomethyl)-2,6-dichlorobenzeneacetamide(Tenex), is structurally related to clonidine hydrochloride andguanabenz acetate and shares many of their pharmacologicalproperties. The drug has a longer duration of action than eitherclonidine hydrochloride or guanabenz acetate. It lasts upto 24 hours. It also requires much longer (8–12 hours) for apeak effect to occur after the drug is administered.

Biologische Aktivit?t

Selective α 2A -adrenoceptor agonist (K d = 31 nM). Displays 60-fold selectivity over α 2B -adrenoceptors. Also available as part of the α 2 -Adrenoceptor Tocriset™ .

Pharmakokinetik

The pharmacokinetic properties for guanfacine differ from those of clonidine, guanabenz, and α-methyldopa. At pH 7.4, guanfacine is predominately (67%) in the nonionized, lipid-soluble base form, which accounts for its high oral bioavailability (>80%). Following an oral dose, peak plasma concentrations occur in 1 to 4 hours, with a relatively long elimination half-life of 14 to 23 hours. The maximum blood pressure response occurs in 8 to 12 hours after oral administration and is maintained up to 36 hours following its discontinuation. Following IV dosing, guanfacine achieves the highest concentrations in liver and kidney, with low concentrations in the brain. Guanfacine is 64% bound to plasma proteins. In patients with hepatic or renal impairment, its elimination half-life may be prolonged.
Guanfacine is metabolized principally by hepatic hydroxylation to its inactive metabolite, 3-hydroxyguanfacine (20%), which is eliminated in the urine as its glucuronide (30%), sulfate (8%), or mercapturic acid conjugate (10%), and 24 to 37% is excreted as unchanged guanfacine. Its nearly complete bioavailability suggests no evidence of any first-pass effect. Guanfacine and its inactive metabolites are excreted principally in urine, with approximately 80% of its oral dose excreted in urine within 48 hours.

Clinical Use

Overall, the therapeutic applications for guanfacine are similar to those of the other centrally acting α2-adrenergic agonists and methyldopa. It has been effective as monotherapy in the treatment of patients with mild to moderate hypertension. One advantage for guanfacine is its once-a-day dosing schedule. The use of diuretics to prevent accumulation of fluid may allow a reduction in the dosage for guanfacine.

Nebenwirkungen

Overall, although the frequency of troublesome adverse effects produced by guanfacine is similar to that produced by clonidine and the other centrally acting sympatholytics, their incidence and severity are lower with guanfacine. Unlike clonidine, abrupt discontinuation of guanfacine rarely results in rebound hypertension. When a withdrawal syndrome has occurred, its onset was slower and its symptoms less severe than the syndrome observed with clonidine.

N-(Aminoiminomethyl)-2,6-dichlorphenylacetamidmonohydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


N-(Aminoiminomethyl)-2,6-dichlorphenylacetamidmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 209)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5858 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5893 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32951 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29885 58
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CONIER CHEM AND PHARMA LIMITED
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sales@conier.com China 49374 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569266 15319487004
1015@dideu.com China 4087 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196
sale04@alfachem.cn China 13502 58

29110-48-3(N-(Aminoiminomethyl)-2,6-dichlorphenylacetamidmonohydrochlorid)Verwandte Suche:


  • bs100-141
  • estulic
  • lon798
  • n-(aminoiminomethyl)-2,6-dichlorobenzeneacetamidehydrochloride
  • n-(aminoiminomethyl)-2,6-dichloro-benzeneacetamidmonohydrochloride
  • n-amidino-2-(2,6-dichlorophenyl)acetamidehydrochloride
  • N (AMINOIMINOMETHYL)-2,6-DICHLOROBENZENEACETAMIDE HYDROCHLORIDE SALT
  • [(2,6-DICHLOROPHENYL)ACETYL]GUANIDINE HYDROCHLORIDE
  • GUANFACINE HCL
  • GUANFACINE HYDROCHLORIDE SALT
  • N-(aminoiminomethyl)-2,6-dichlorophenylacetamide monohydrochloride
  • GUANFACIN HYDROCHLORIDE
  • Guanfascine
  • Guarfacine
  • Guanfacine Hydrochloride (125 mg)
  • BenzeneacetaMide, N-(aMinoiMinoMethyl)-2,6-dichloro-, Monohydrochloride
  • BenzeneacetaMide,N-(aMinoiMinoMethyl)-2,6-dichloro-, hydrochloride (1:1)
  • Guanfacine Hydrochloride >
  • GUANFACINE HCL USP/EP/BP
  • Guanfacine HCL powder
  • Guanfacine HCL Working Standard
  • Guanfacine HydrochlorideQ: What is Guanfacine Hydrochloride Q: What is the CAS Number of Guanfacine Hydrochloride Q: What is the storage condition of Guanfacine Hydrochloride Q: What are the applications of Guanfacine Hydrochloride
  • N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride[Guanfacine
  • Guanfacine Hydrochloride (1302101)
  • GUANFACINE HYDROCHLORIDE
  • Intuniv
  • Tenex
  • N-amido-2- (2,6-dichlorophenyl) acetamide hydrochloride
  • 29110-48-3
  • C9H9Cl2N3OHCl
  • C9H10Cl3N3O
  • C9H9Cl2N3OClH
  • Inhibitors
  • API
  • Amines
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Adrenoceptor
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