HERBIMYCIN A Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Verwenden

Herbimycin A is the major analogue of a complex of benzoquinone ansamycin antibiotics isolated from a Streptomyces hygroscopicus. Herbimycin A inhibits the 90-kDa heat-shock protein (Hsp90) which provides essential chaperone support to various signal transduction molecules, including certain steroid hormone receptors and select kinases. Herbimycin also inhibits protein tyrosine kinase and angiogenesis.

Definition

ChEBI: A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.

Allgemeine Beschreibung

A cell-permeable, potent inhibitor of protein tyrosine kinases. Inhibits p60^v-src (IC₅₀ = 12 μM) autophosphorylation. Irreversibly binds to the sulfhydryl groups of the kinase. Dose-dependently inhibits PDGF-induced phospholipase D activation (IC₅₀ = 8 μg/ml). Also, reported to inhibit c-src related bone resorption (IC₅₀ = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane and blocks anti-CD3 monoclonal antibody-induced apoptosis of thymocytes. Several mammalian cell lines transformed with tyrosine kinase oncogenes (src, abl, fps, ros, yes, erbB) show reversion from the transformed to the normal phenotype after treatment with herbimycin A.

Biologische Aktivit?t

Ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60 v-src and p210 BCR-ABL . Exhibits antiangiogenic activity in endothelial cells in vitro . Also inhibits Hsp90 and impairs recovery from heat shock.

HERBIMYCIN A Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

HERBIMYCIN A Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19741	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Shaanxi Xianhe Biotech Co., Ltd	+8617709210191	Jerry@xhobio.com	China	882	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-400-6206333 18521732826	market@aladdin-e.com	China	25003	65
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4674	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60

70563-58-5()Verwandte Suche:

---

• HERBIMYCIN A
• HERBIMYCIN A, STREPTOMYCES HYGROSCOPICUS
• HERBIMYCIN A, STREPTOMYCES SPECIES
• herbimycin A from streptomyces hygros-copicus
• herbimycin A from streptomyces*hygroscopicus
• Herbimycin A, Streptomyces sp.
• C11225
• [(2R,3S,5S,6R,7S,8E,10R,11S,12E,14E)-2,5,6,11-Tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl]carbamate
• (15R)-17-Demethoxy-15-methoxy-11-O-methylgeldanamycin
• HerbiMycin AHerbiMycin A froM StreptoMyces hygros
• HerbiMycin, TAN 420F
• Geldanamycin,17-demethoxy-15-methoxy-11-O-methyl-, (15R)-
• (15r)-geldanamyci
• HERBIMYCIN A FROM STREPTOMYCES HYGROS- COPICUS, 100 UG*
• antibiotictan420f
• herbimycin
• Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem
• HERBIMYCIN A USP/EP/BP
• 70563-58-5
• C30H42N2O9
• Antibiotics G-M
• Antibiotics A to Z
• Antibiotics
• BioChemical
• Antibiotic
• Heat Shock Protein 90