2-Chlorpyrimidin-4,5-diamin
|
|
|
- CAS-Nr.
- 14631-08-4
- Bezeichnung:
- 2-Chlorpyrimidin-4,5-diamin
- Englisch Name:
- 2-Chloro-4,5-diaminopyrimidine
- Synonyma:
- 2-CHLOROPYRIMIDINE-4,5-DIAMINE;IFLAB-BB F1371-0155;6-Chloro-2,3-PyriMidinediaMine;2-CHLORO-4,5-DIAMONOPYRIMIDINE;4,5-DIAMINO-2-CHLOROPYRIMIDINE;2-CHLORO-4,5-DIAMINOPYRIMIDINE;4,5-Pyrimidinediamine, 2-chloro-;(4-amino-2-chloro-pyrimidin-5-yl)amin;4,5-Pyrimidinediamine, 2-chloro- (9CI);(4-amino-2-chloro-pyrimidin-5-yl)amine
- CBNumber:
- CB0754718
- Summenformel:
- C4H5ClN4
- Molgewicht:
- 144.56
- MOL-Datei:
- 14631-08-4.mol
|
2-Chlorpyrimidin-4,5-diamin Eigenschaften
- Schmelzpunkt:
- 220 °C (decomp)
- Siedepunkt:
- 417.9±25.0 °C(Predicted)
- Dichte
- 1.564±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.61±0.10(Predicted)
- CAS Datenbank
- 14631-08-4(CAS DataBase Reference)
2-Chlorpyrimidin-4,5-diamin Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
A mixture of 2-chloro-5-nitropyrimidin-4-amine (1.0 g, 5.7 mmol) and SnCl2·2H2O (5.2 g, 22.9 mmol) in EtOH (55 mL) under N2 was heated to 80 °C and stirred for two hours. The mixture was then concentrated under reduced pressure. EtOAc and Celite were added to the residue, and the mixture was basified with saturated Na2CO3 (aq.) to pH 9- 10. The mixture was filtered through a pad of Celite and washed with EtOAc. The organic layer was separated, washed with brine, dried (Na2SO4), and concentrated in a vacuum. The residue was purified on ISCO (20 g silica gel column, EtOAc/hexanes 0~100 per cent) to give 2-Chloro-4,5-diaminopyrimidine (0.41 g 49 per cent).
2-Chlorpyrimidin-4,5-diamin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Chlorpyrimidin-4,5-diamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 131)Lieferanten
14631-08-4(2-Chlorpyrimidin-4,5-diamin)Verwandte Suche:
- IFLAB-BB F1371-0155
- 2-CHLORO-4,5-DIAMINOPYRIMIDINE
- 4,5-DIAMINO-2-CHLOROPYRIMIDINE
- (4-amino-2-chloro-pyrimidin-5-yl)amine
- 4,5-Pyrimidinediamine, 2-chloro- (9CI)
- 2-CHLORO-4,5-DIAMONOPYRIMIDINE
- 6-Chloro-2,3-PyriMidinediaMine
- (4-amino-2-chloro-pyrimidin-5-yl)amin
- 4,5-Pyrimidinediamine, 2-chloro-
- 2-CHLORO-4,5-DIAMINOPYRIMIDINE ISO 9001：2015 REACH
- 2-CHLOROPYRIMIDINE-4,5-DIAMINE
- 14631-08-4
- Heterocycle-Pyrimidine series
- PYRIMIDINE
- APIs & Intermediate
- pharmacetical
- Building Blocks
