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G3139

G3139 Struktur
CAS-Nr.
Englisch Name:
G3139
Synonyma:
G3139;BCL-2, AS;5'-TCTCCCAGCGTGCGCCAT-3';5'-TCTCCCAGCGTGCGCCAT-3', SODIUM SALT;BCL-2 ANTISENSE OLIGONUCLEOTIDE, SODIUM SALT
CBNumber:
CB0664040
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

G3139 Eigenschaften

storage temp. 
-70°C

Sicherheit

G3139 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

As the representative antisense oligonucleotide, Oblimersen (G3139, Genasense) is an 18-base phosphor- othioate antisense oligodeoxynucleotide that was developed to treat CLL, B-cell lymphoma, lung, and breast cancers. Oblimersen binds with the first six codons of Bcl-2 mRNA open reading frame and mediates RNA cleavage by RNase H to downregulate Bcl-2. The antitumor effect of oblimersen is associated with both apoptotic and nonapoptotic pathways.
In the apoptotic pathway, Bcl-2 downregulation by oblimersen could increase Bax and poly (ADP-ribose) Polymerase (PARP) to release cytochrome cand Smac/DIABLO to pro- mote apoptosis. For the nonapoptotic pathway, Bcl-2 downregulation by oblimersen may have promoted the release of Beclin-1 to induce autophagic cell death. In addition, oblimersen has been shown to enhance tumor immunity by promoting polyclonal antibodies production and activating dendritic cell maturation. In monotherapy, oblimersen failed in phase-III clinical trials of treating lymphoid malignancies, which could be due to limited uptake, intracellular compartmentalization, or degradation by nuclear enzymes. On the other hand, oblimersen has been found to increase the overall survival when combined with other chemotherapeutic drugs, such as dacarbazine, fludarabine, and cyclophosphamide, by increasing the sensitivity of those drugs.

G3139 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


G3139 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 2)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Kanto Chemical Co., Inc. --
reag-info@gms.kanto.co.jp Japan 6756 74
EMD Biosciences, Inc. --
technical@calbiochem.com United States 6529 66

  • 5'-TCTCCCAGCGTGCGCCAT-3'
  • 5'-TCTCCCAGCGTGCGCCAT-3', SODIUM SALT
  • G3139
  • BCL-2 ANTISENSE OLIGONUCLEOTIDE, SODIUM SALT
  • BCL-2, AS
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