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Flecainide

Flecainide Struktur
54143-55-4
CAS-Nr.
54143-55-4
Englisch Name:
Flecainide
Synonyma:
Flecaine;Flecanide;FLECAINIDE;Flecainide-d4;rac Flecainide;FLECAINTDE BASE;Flecainide USP/EP/BP;(±)-Flecainide solution;N-(Piperidin-2-ylmethyl);-2,5-bis(2,2,2-trifluoroethoxy)
CBNumber:
CB0663265
Summenformel:
C17H20F6N2O3
Molgewicht:
414.34
MOL-Datei:
54143-55-4.mol

Flecainide Eigenschaften

Schmelzpunkt:
105-1070C
Siedepunkt:
434.9±45.0 °C(Predicted)
Dichte
1.286±0.06 g/cm3(Predicted)
Flammpunkt:
9℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
pKa 9.3 (Uncertain)
Farbe
White to Off-White
BCS Class
1 or 2?
CAS Datenbank
54143-55-4(CAS DataBase Reference)
NIST chemische Informationen
Benzamide, n-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-(54143-55-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher F,T
R-S?tze: 11-23/24/25-39/23/24/25
S-S?tze: 7-16-36/37-45
RIDADR  3249
WGK Germany  1
HazardClass  6.1(b)
PackingGroup  III
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung GHS hazard pictogramssrc="/GHS02.jpg" width="20" height="20" /> P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Sch?digt die Organe. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P210 Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P311 GIFTINFORMATIONSZENTRUM/Arzt anrufen.

Flecainide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

From the chemical point, flecainide is an analog of procainamide, to which a 2.2.2-trifluoroethoxyl group was added at C2 and C3 of the benzene ring, and a diaminoethyl side chain is ended in the piperidine ring.

Chemische Eigenschaften

White Crystalline Powder

Verwenden

Flecainide, as with other local anesthetics, is used for naturally occurring ventricular arrhythmia.

Definition

ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prev nt and treat tachyarrhythmia (abnormal fast rhythm of the heart).

Weltgesundheitsorganisation (WHO)

The membrane-stabilizing antiarrhythmic agent flecainide was introduced into medicine in 1982. The decision to delete the indications for patients with asymptomatic and less severe symptomatic ventricular arrhythmias was taken on the basis of the results of a trial (CAST study) that showed a two-fold increase in deaths in post-myocardiac patients taking flecainide compared with the placebo group.

Hazard

Human systemic effects.

Clinical Use

Flecainide (Tambocor) is a fluorinated aromatic hydrocarbon examined initially for its local anesthetic action and subsequently found to have antiarrhythmic effects. Flecainide inhibits the sodium channel, leading to conduction slowing in all parts of the heart, but most notably in the His-Purkinje system and ventricular myocardium. It has relatively minor effects on repolarization. Flecainide also inhibits abnormal automaticity.
Flecainide is effective in treating most types of atrial arrhythmias. It is also used for life-threatening ventricular arrhythmias. However, flecainide should be used with extreme caution in any patient with structural heart disease. Flecainide crosses the placenta, with fetal levels reaching approximately 70% of maternal levels. In many centers, it is the second-line drug after digoxin for therapy of fetal arrhythmias. Because of the high incidence of proarrhythmia, initiation of therapy or significant increases in dosing should be performed only on inpatients.

Nebenwirkungen

Most adverse effects occur within a few days of initial drug administration. The most frequently reported effects are dizziness, light-headedness, faintness, unsteadiness, visual disturbances, blurred vision (e.g., spots before the eyes, difficulty in focusing), nausea, headache, and dyspnea.
Worsening of heart failure and prolongation of the PR and QRS intervals are likely to occur with flecainide, and an increased risk of proarrhythmia has been reported.

Arzneimittelwechselwirkung

In patients whose condition has been stabilized by flecainide, the addition of cimetidine may reduce the rate of flecainide’s hepatic metabolism, increasing the potential for toxicity. Flecainide may increase digoxin concentrations on concurrent administration.

Vorsichtsma?nahmen

Flecainide is contraindicated in patients with preexisting second- or third-degree heart block or with bundle branch block unless a pacemaker is present to maintain ventricular rhythm. It should not be used in patients with cardiogenic shock.

Flecainide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Flecainide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 116)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
Finetech Industry Limited
+86-27-87465837 +8618971612321
info@finetechnology-ind.com China 9639 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58

54143-55-4()Verwandte Suche:


  • N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • FLECAINTDE BASE
  • Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-
  • Flecaine
  • rac Flecainide
  • Flecainide-d4
  • N-(Piperidin-2-ylMethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzaMide
  • -2,5-bis(2,2,2-trifluoroethoxy)
  • N-(Piperidin-2-ylmethyl)
  • n-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • (±)-Flecainide solution
  • FLECAINIDE
  • Flecanide
  • Flecainide USP/EP/BP
  • 1-Piperazinecarboxylicacid,4-(3-bromopropyl)-,1,5-dimethylethylester
  • 54143-55-4
  • 35480-31-5
  • C17H20F6N2O3
  • C17H2OF6N2O3
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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