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CD38 inhibitor 78c

CD38 inhibitor 78c Struktur
1700637-55-3
CAS-Nr.
1700637-55-3
Englisch Name:
CD38 inhibitor 78c
Synonyma:
78c;cd38-1;MDK7553;MDK 7553;MDK-7553;CD38i_78c;CD38IN-78c;CD38 IN-78c;CD38-IN-78c;Compound-78c
CBNumber:
CB04667733
Summenformel:
C22H27N3O3S
Molgewicht:
413.53
MOL-Datei:
1700637-55-3.mol

CD38 inhibitor 78c Eigenschaften

Siedepunkt:
589.8±50.0 °C(Predicted)
Dichte
1.27±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO : 25 mg/mL (60.46 mM; ultrasonic and warming and heat to 60°C)
Aggregatzustand
A solid
pka
3.17±0.20(Predicted)
Farbe
Light yellow to brown
InChI
InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17-
InChIKey
VJQALSOBHVEJQM-QAQDUYKDSA-N
SMILES
N1(C)C2=C(C=C(C3SC=NC=3)C=C2)C(N[C@@H]2CC[C@@H](OCCOC)CC2)=CC1=O

Sicherheit

CD38 inhibitor 78c Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Thiazoloquin(az)olin(on)es, such as the small molecule 78c, have been identified as potent CD38 inhibitors (CD38i). CD38 inhibitor 78c is a potent, reversible, and uncompetitive inhibitor of CD38. 78c reverses age-related NAD+ decline and ameliorates several metabolic, structural, and molecular ageing features in chronologically aged and progeroid mice. The CD38 inhibitor 78c increases naturally aged mice's lifespan and health span. In addition to a 10% increase in median survival, 78c improved exercise performance, endurance, and metabolic function in mice. The effects of 78c were different between the sexes[1-2].

Verwenden

4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone is a useful compound and has been evaluated for use as CD38 inhibitors.

CD38 inhibitor 78c Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

CD38 inhibitor 78c Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 61)Lieferanten
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Nantong HI-FUTURE Biology Co., Ltd.
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Hubei Chuchang Biotech Co., Ltd.
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InvivoChem 		+1-708-310-1919 +1-13798911105
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Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328
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TargetMol Chemicals Inc.
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Hebei Miaoyin Technology Co.,Ltd 		+86-17367732028 +86-17367732028
 kathy@hbyinsheng.com China 3512 58
  • CD38 inhibitor 78c
  • CD38 inhibitor 1
  • 2(1H)-Quinolinone, 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-
  • CD38 inhibitor 1 (compound 78c)
  • 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone
  • 4-((trans-4-(2-Methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one
  • cd38-1
  • CD38 inhibitor 1,Inhibitor,inhibit,CD-38 inhibitor 1
  • 4-[[trans-4-(2-Methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)quinolin-2(1H)-one
  • 4- (trans 4- (2-methoxyethoxy) cyclohexyl) amino) -1-methyl-6- (thiazol-5-yl) quinoline-2 (1H) - one
  • CD38 IN-78c
  • CD38-IN-78c
  • CD38IN-78c
  • Cluster of Differentiation 38 Inhibitor
  • Compound-78c
  • MDK 7553
  • MDK7553
  • MDK-7553
  • 78c
  • CD38i_78c
  • CD38IN-78c: CD38 inhibitor 78c
  • 1700637-55-3
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